Tag: <span>proteins</span>

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Investigational drug for Alzheimer’s disease may help autistic children

Reviewed by Emily Henderson, B.Sc. An extensive international study led by Prof. Illana Gozes of Tel Aviv University’s Department of Human Molecular Genetics and Biochemistry found deposits of the tau protein typically found in Alzheimer’s patients in tissues taken from the postmortem brain of a 7-year-old autistic child. The child suffered from the ADNP syndrome,...

Some ‘inert’ drug ingredients may be biologically active
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Some ‘inert’ drug ingredients may be biologically active

by University of California, San Francisco Some supposedly inert ingredients in common drugs—such as dyes and preservatives—may potentially be biologically active and could lead to unanticipated side effects, according to a preliminary new study by researchers from the UC San Francisco School of Pharmacy and the Novartis Institutes for BioMedical Research (NIBR). Most medications include...

L-type calcium channel blockers may contribute to heart failure, study finds
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L-type calcium channel blockers may contribute to heart failure, study finds

by Sara Lajeunesse, Pennsylvania State University L-type calcium channel blockers (LCCBs)—the most widely used drugs for treating hypertension—may harm the heart as much as help it, according to a new study. The research team, led by Penn State, found that in rats and human cells in vitro, LCCBs cause changes in blood vessels—known as vascular...

Antiviral method against herpes paves the way for combatting incurable viral infections
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Antiviral method against herpes paves the way for combatting incurable viral infections

by Lund University Researchers at Lund University in Sweden have discovered a new method to treat human herpes viruses. The new broad-spectrum method targets physical properties in the genome of the virus rather than viral proteins, which have previously been targeted. The treatment consists of new molecules that penetrate the protein shell of the virus...

The immune system: Knocked off balance
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The immune system: Knocked off balance

by Ludwig Maximilian University of Munich The immune system: Knocked off balanceInstead of protecting us, the immune system can sometimes go awry, as in the case of autoimmune diseases and allergies. An LMU team has dissected how mast cells regulate their calcium levels to keep the immune response under control. Credit: IMCES UK Essen/LMU Instead...

Erectile dysfunction drugs can help cells destroy misfolded proteins
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Erectile dysfunction drugs can help cells destroy misfolded proteins

by Harvard Medical School The aberrant buildup of misfolded proteins is a hallmark of a host of disorders, including neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Aggregates of these toxic proteins wreak havoc on the function of cells, tissues, and organs, and despite intensive research over many decades, there are still no effective means to...

Researchers identify possible drug target for prostate cancer
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Researchers identify possible drug target for prostate cancer

by Boston University School of Medicine Researchers from Boston University School of Medicine (BUSM) have discovered that the protein BRD4 could be an important new target to prevent castration-resistant prostate cancer metastases. Castration-resistant prostate cancer is a highly aggressive form of prostate cancer that often leads to the development of lethal metastases that kills more...

Could THIS be the secret to living past 100? Scientists discover ‘master circuit’ that controls how cells age – and say reprogramming it could ‘dramatically’ lengthen lifespan
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Could THIS be the secret to living past 100? Scientists discover ‘master circuit’ that controls how cells age – and say reprogramming it could ‘dramatically’ lengthen lifespan

By NATALIE RAHHAL ACTING US HEALTH EDITOR University of California, San Diego, researchers found a cellular ‘master circuit’ that determines which of two ways yeast cells age in yeast By tweaking how proteins involved in the circuit interact, the scientists were able to create an entirely new pathway of aging for yeast cells Cells lived...