Anaplastic large-cell lymphomas (ALCL) are rare cancers of the white blood cells. New research from the international ERIA consortium, led by scientists in Vienna, has now shown that the same signaling pathway is essential to the growth of cancer cells in various forms of ALCL: TYK2 (tyrosine kinase 2, an important component of the immune system) prevents...
Tag: <span>proteomics</span>
Post
mRNA polyplexes with post-conjugated GALA peptides efficiently target, transfect and activate antigen presenting cells.
Vaccines based on messenger RNA (mRNA) have emerged as potent systems to elicit CD8+ T cell responses against various cancers and viral infectious diseases. The efficient intracellular delivery of mRNA molecules encoding antigens into the cytosol of antigen-presenting cells (APCs) is still challenging, requiring cell attachment, active uptake and subsequent endosomal escape. Here, we report...
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