Doug Brunk An experimental topical phosphodiesterase 4 (PDE4) inhibitor showed superior efficacy to vehicle in patients with mild to moderate atopic dermatitis (AD) and plaque psoriasis, results from a phase 2a study showed. PDE4 inhibitors are a promising therapeutic target for inflammatory diseases because “they can increase cyclic adenosine monophosphate levels and subsequently reduce the...
Tag: <span>Psoriasis</span>
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New program for psoriasis patients highlights cardiovascular risk
by Perelman School of Medicine at the University of Pennsylvania Credit: Unsplash/CC0 Public DomainAlmost 30% of the patients in a pilot program for those with psoriasis that was devised by researchers from the Perelman School of Medicine at the University of Pennsylvania were identified as having undiagnosed, elevated risk for cardiovascular disease. Those patients were then...
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Psoriasis not caused by spontaneous mutations in skin cells
Genetic analysis of psoriasis shows somatic mutations are not linked to the development or the spread of the condition.Peer-Reviewed Publication WELLCOME TRUST SANGER INSTITUTE Psoriasis — a chronic skin condition — is not caused or spread by spontaneous genetic mutations in the skin, new research suggests. The team, from the Wellcome Sanger Institute and collaborators,...
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Study Validates Use of New Psoriatic Arthritis Prediction Tool
Doug Brunk A new predictive tool known as the Psoriatic Arthritis Risk Estimation Tool (PRESTO) is now available to help clinicians estimate the risk of psoriatic arthritis (PsA) in their patients with psoriasis. Dr Lihi Eder Though it requires further validation, researchers led by rheumatologist Lihi Eder, MD, PhD, of the Women’s College Research Institute...
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Vitamin D linked to psoriasis severity in large study
A study found a link between vitamin D levels and the severity of psoriasis. Raymond Forbes LLC/Stocksy Psoriasis is an autoimmune skin disorder characterized by raised, inflamed and scaly patches of skin that can also be itchy and painful. The severity of psoriasis varies greatly from person to person. New research shows that low vitamin D levels...
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Early intervention for psoriasis with guselkumab tied to complete response
by Lori Solomon Guselkumab is consistently effective across subpopulations for the treatment of moderate-to-severe plaque psoriasis, according to a study published June 1 in the Journal of the European Academy of Dermatology & Venereology. Knut Schäkel, M.D., from Heidelberg University Hospital in Germany, and colleagues evaluated the impact of early disease intervention on clinical responses following...
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Psoriasis tied to elevated risk for celiac disease
by Lori Solomon Individuals with psoriasis have double the odds of having celiac disease (CD) versus individuals without psoriasis, according to a research letter published online Feb. 9 in the Journal of the American Academy of Dermatology. Marina Z. Joel, from the Johns Hopkins University School of Medicine in Baltimore, and colleagues examined the association between psoriasis and...
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Cardiovascular risk in psoriasis
By Bhavana Kunkalikar Feb 6 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in the Journal of Clinical Medicine, researchers explored the impact of biological interventions in reducing cardiovascular risk among psoriasis patients. Study: Biologics for Reducing Cardiovascular Risk in Psoriasis Patients. Image Credit: wisely/Shutterstock Background Psoriasis manifests as a chronic inflammatory skin condition...
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Psoriasis diagnoses in primary care may be delayed by up to five years
by University of Manchester Credit: Estzer Miller on Pixabay Psoriasis may be underdiagnosed in UK primary care settings, according to research led by researchers from The University of Manchester. The findings, published in the British Journal of General Practice, show that missed opportunities for early diagnosis of the potentially debilitating condition are relatively common in general practice....
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Tapinarof effective for longer-term treatment of plaque psoriasis
Four in 10 plaque psoriasis patients achieve complete disease clearance with tapinarof cream, 1 percent, according to a study published online June 26 in the Journal of the American Academy of Dermatology. Bruce Strober, M.D., Ph.D., from Yale University in New Haven, Connecticut, and colleagues assessed the long-term safety, efficacy, remittive effect, durability of response, and...