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True behavior of the ‘pleasure molecule’ will reshape treatment of psychiatric diseases and addiction
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True behavior of the ‘pleasure molecule’ will reshape treatment of psychiatric diseases and addiction

by Aaron Conley,  Vanderbilt University Figure 1. Dopamine in the nucleus accumbens core does not track reward prediction error in negative reinforcement tasks (A) Positive reinforcement task. (B) Dopamine was recorded via fiber photometry using dLight1.1. (C) Mice made more active than inactive responses during the post-training session (t6 = 3.18, p = 0.024; n = 6). (D and E)...

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Genomic dark matter activity connects Parkinson’s and psychiatric diseases

Comprehensive study reveals an expanding universe of ‘darkest of the dark matter‘ RNAs in dopamine-producing cells in our brains BRIGHAM AND WOMEN’S HOSPITAL Dopamine neurons are located in the midbrain, but their tendril-like axons can branch far into the higher cortical areas, influencing how we move and how we feel. New genetic evidence has revealed that these...