The new algorithm was trained on dozens of complete human genomes and has a 95% accuracy rate at identifying complex structural variants, which can consist of long stretches of DNA. The chromosome on the right has a complex structural variant—a missing segment of DNA (B, orange) and a section of DNA that flipped around backwards...
Tag: <span>psychiatric diseases</span>
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True behavior of the ‘pleasure molecule’ will reshape treatment of psychiatric diseases and addiction
by Aaron Conley, Vanderbilt University Figure 1. Dopamine in the nucleus accumbens core does not track reward prediction error in negative reinforcement tasks (A) Positive reinforcement task. (B) Dopamine was recorded via fiber photometry using dLight1.1. (C) Mice made more active than inactive responses during the post-training session (t6 = 3.18, p = 0.024; n = 6). (D and E)...
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Genomic dark matter activity connects Parkinson’s and psychiatric diseases
Comprehensive study reveals an expanding universe of ‘darkest of the dark matter‘ RNAs in dopamine-producing cells in our brains BRIGHAM AND WOMEN’S HOSPITAL Dopamine neurons are located in the midbrain, but their tendril-like axons can branch far into the higher cortical areas, influencing how we move and how we feel. New genetic evidence has revealed that these...