News Release 4-Sep-2024 Misha Kudryshev’s lab at the Max Delbrück Center has identified a potentially new drug target for serotonin, which is involved in depression and schizophrenia Peer-Reviewed PublicationMax Delbrück Center for Molecular Medicine in the Helmholtz Association image: Researchers have identified an intermediate form of the 5-HT3A serotonin receptor (blue). In its final form,...
July 27, 2024 by Allessandra DiCorato, Broad Institute of MIT and Harvard Credit: CC0 Public DomainWhen Ralda Nehme, a cell biologist and neuroscientist, first started her lab at the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard in 2018, she realized a gap in the field. She was adept at...
A research review in the New England Journal of Medicine highlights the growing concern over cannabis use disorder, exacerbated by increased cannabis potency and usage. This disorder, affecting a significant portion of Americans, particularly young adults, is often accompanied by other psychiatric conditions. Credit: SciTechDaily.com Review article published in the New England Journal of Medicine...
by Holly Moody-Porter, University of Maryland School of Medicine Credit: Yash Lucid from Pexels The widespread use of cannabis (marijuana) and its increased potency are associated with a rise in cannabis-related psychiatric conditions, according to a new University of Maryland School of Medicine (UMSOM) review article that was published in the New England Journal of Medicine....
Researchers at the University of Toronto are inching closer to realizing a life-saving brain cancer treatment by using gold nanoparticles to make radiation therapy more effective and less toxic for patients. In their battle against glioblastoma multiforme (GBM), a rare, fast-growing cancer that begins in the brain, the multidisciplinary team has discovered that the nanoparticles can keep...
by The Mount Sinai Hospital Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.110877 Researchers from the Icahn School of Medicine at Mount Sinai have applied a novel stem cell model to map disease risk variants in human neurons, which could help provide insights into the biological mechanisms that underlie neuropsychiatric disorders such as autism and schizophrenia. The...
A new study in macaque monkeys has shed light on which parts of the brain support credit assignment processes (how the brain links outcomes with its decisions) and, for the first time, how low-intensity transcranial ultrasound stimulation (TUS) can modulate both brain activity and behaviours related to these decision-making and learning processes. While currently developed in an...
by Forschungszentrum Juelich Pictorial representations of the association and architecture of the DISC1 regulatory domain in fibrils and symmetric oligomers. Credit: Abhishek Cukkemane et al. In a new study, scientists from Forschungszentrum Jülich and Heinrich Heine University Düsseldorf (HHU) have demonstrated for the first time that improper protein conformation is linked to the development of...
by The Mount Sinai Hospital Level of association of more than 7.5 million common genetic variants with suicide attempt, before and after adjusting for psychiatric disorders. Genetic variants above the gray line pass the statistical significance level. Credit: Niamh Mullins, PhD, Assistant Professor of Psychiatry, Icahn School of Medicine at Mount Sinai In the largest genetic...
by Will Doss, Northwestern University Confocal microscope image of the mouse hippocampus showing colocalization of ankyrin-G (green) and DAGLA (red) in the same neurons. Credit: Northwestern University Northwestern Medicine scientists discovered an unexpected connection between a synapse protein that has been implicated in neuropsychiatric disorders and the endocannabinoid pathway, according to a study published in Biological Psychiatry....
