by Delthia Ricks, Medical Xpress TCS2 protein reduction in SMA-positive areas in small PAs from SM22-Tsc+/- mice. a: SM22-Cre mice were bred with Tsc2flox/flox mice to generate SM22-Tsc+/- mice. b: Immunohistochemical analysis of lung tissue sections of SM22-Tsc2+/- mice to detect TSC2 (red), smooth muscle α-actin (SMA) (green), and DAPI (blue). Representative images from n=5 WT and 7 SM22-Tsc2+/- mice...
Findings reported in The American Journal of Pathology suggest dofetilide may counteract pathological changes in potassium channels associated with pulmonary arterial hypertension in humans and rats Philadelphia, December 12, 2019 – High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a potentially fatal disease caused by obstruction of blood flow in...
A team of Cleveland Clinic researchers found that a common heart disease medication, beta blockers, may help treat pulmonary arterial hypertension (PAH), a debilitating lung disease. Caused by high blood pressure in the pulmonary arteries, PAH is a progressive disease which usually leads to right-sided heart failure and death within five to seven years of diagnosis. In fact,...
