July 26, 2024 by Sichuan International Medical Exchange and Promotion Association Cordyceps sinensis (CS) improved mitochondrial dysfunction in bleomycin-induced BEAS-2B cells. (A) Representative transmission electron microscopy (TEM) images of BEAS-2B cells in the control, model, and CS groups. Credit: MedComm – Future Medicine (2024). DOI: 10.1002/mef2.91A study from China has reported that Cordyceps sinensis (CS),...
NEWS RELEASE 12-JUN-2024 Peer-Reviewed PublicationTSINGHUA UNIVERSITY PRESS IMAGE: DURING FIBROSIS PROGRESSION, ISM1-/- MICE EXHIBITED ENHANCED CELLULAR SENESCENCE IN THE ALVEOLAR TYPE II EPITHELIAL (AT2) CELLS WITH INCREASED RELEASE OF SENESCENCE ASSOCIATED PRO-INFLAMMATORY FACTORS WHICH LEAD TO ENHANCED IMMUNE CELL INFILTRATION, RELEASE OF PRO-FIBROTIC MEDIATORS PROMOTING THE ACTIVATION OF MYOFIBROBLASTS WITH EXCESSIVE COLLAGEN DEPOSITION, RESULTING IN...
by University of Michigan Credit: CC0 Public DomainBacteria in the mouth may play a role in survival from idiopathic pulmonary fibrosis (IPF), finds a new study led by researchers from the University of Michigan and the University of Virginia. The findings come from a larger analysis of the role of the lung microbiome and IPF. Working...
Peer-Reviewed Publication UNIVERSITY OF VIRGINIA HEALTH SYSTEM RESEARCHER JOHN KIM, MD, IS A PULMONARY AND CRITICAL CARE EXPERT AT UVA HEALTH AND THE UNIVERSITY OF VIRGINIA SCHOOL OF MEDICINE.CREDIT: UVA HEALTH Could healthy fats found in nuts and fish slow the progression of potentially deadly lung scarring known as pulmonary fibrosis and delay the need...
by National Jewish Health Credit: Pixabay/CC0 Public Domain Researchers have shown that the medication saracatinib shows promise as a treatment for idiopathic pulmonary fibrosis (IPF). Saracatinib worked as well or better than two approved drugs at reducing tissue scarring in preclinical models of IPF according to the study published in the American Journal of Respiratory and...
by The Spanish National Cancer Research Centre Efficient Trf1 deletion in lung fibroblasts upon tamoxifen administration. a Generation of the conditional knockout mouse model in which Trf1 was deleted in fibroblasts using the Cre recombinase driven by the Col1a2 promoter. Trf1lox, KFPLox-LSL-Lox, and Col1a2-CreERT2 alleles are depicted before and after Cre-mediated excision. b Tamoxifen (TMX)...
by University of Chicago Credit: Pixabay/CC0 Public Domain In the last decade, timely and efficient diagnoses of idiopathic pulmonary fibrosis (IPF), a lethal disease that causes scarring of the lung tissue and affects the ability to breathe and be active, has become recognized as a major health challenge. Though not well-known, the disease now has a...
Scientists at the University of Illinois Chicago have developed a treatment for pulmonary fibrosis by using nanoparticles coated in mannose — a type of sugar — to stop a population of lung cells called macrophages that contribute to lung tissue scarring. The cell-targeting method holds promise for preventing this severe lung scarring disease, which can result in...
UNIVERSITY OF ILLINOIS COLLEGE OF AGRICULTURAL, CONSUMER AND ENVIRONMENTAL SCIENCES IMAGE: UNIVERSITY OF ILLINOIS AND MIE UNIVERSITY RESEARCHERS HAVE DETERMINED THE MICROBIAL TOXIN RESPONSIBLE FOR LUNG CELL DEATH IN IDIOPATHIC PULMONARY FIBROSIS AND ACUTE RESPIRATORY DISEASE SYNDROME, AND HAVE DEVELOPED SAFE BLOOD TESTS AND MONOCLONAL ANTIBODY TREATMENTS TO HALT PROGRESSION OF THE DISEASES IN MICE....
by University of California San Francisco Medical Center Credit: Unsplash/CC0 Public Domain Severe injuries to the lung from diseases such as COVID-19 trigger abnormal stem cell repair that alters the architecture of the lung. The aberrant stem cell differentiation in response to injury can prevent the restoration of normal lung function. In a collaborative study between UCSF researchers appearing...
