by Medical College of Georgia at Augusta University Yuqing Huo, MD, PhD, (left) and Qian Ma, PhD. Credit: Michael Holahan, Augusta University The vascular smooth muscle cells that normally give blood vessel walls strength and flexibility proliferate and become destructive in pulmonary hypertension, a typically rapidly progressing condition that makes it hard to get blood...
by American College of Cardiology Credit: Pixabay/CC0 Public Domain Patients with pulmonary arterial hypertension (high blood pressure in the arteries that supply the lungs, also called PAH) had approximately double the reduction in pulmonary vascular resistance (PVR) if they took the PAH medications macitentan (10 mg) and tadalafil (40 mg) together in a single tablet...
by Stefan Zorn, Medizinische Hochschule Hannover Credit: CC0 Public Domain About 1% of the world’s adult population suffers from pulmonary hypertension (PH). Among the many forms of this disease is idiopathic pulmonary arterial hypertension (IPAH), a rare but very severe disease. The term “idiopathic” means that there is no tangible cause for the disease. A...
by Hannover Medical School A microscopic image of the cultured human mesenchymal stem cells from the donor umbilical cord, whose stem cell products in conditioned medium were used for this therapeutic approach. Credit: Ralf Hass, MHH Department of Gynaecology and Obstetrics. Clinical researchers at Hannover Medical School (MHH) have succeeded for the first time in...
MEDICAL COLLEGE OF GEORGIA AT AUGUSTA UNIVERSITY IMAGE: (FROM LEFT) GRADUATE STUDENT ZSUZSANNA BORDAN, DRS. SCOTT BARMAN AND DAVID FULTON. CREDIT: MICHAEL HOLAHAN, AUGUSTA UNIVERSITY AUGUSTA, Ga. (Dec. 16, 2021) – A gene that is overexpressed in some aggressive cancers also appears to be key to the excessive cell proliferation that thickens the walls of pulmonary arteries...
by André Julião, FAPESP In experiments by Brazilian researchers with mice and tumor cell lines, the drug showed potential to combat metastasis. The scientists are planning to conduct clinical trials with patients who are on chemotherapy (representative liver sections of control (c-e) or ambrisentan-treated (f, g) mice are shown, with small red circles indicating tumor metastatic foci. The...
Date:August 29, 2019 Source:Stanford Medicine Summary:Researchers have found that inflammation in the lungs of rats, triggered by something as simple as the flu, may wake up a silent genetic defect that causes sudden onset cases of pulmonary hypertension, a deadly form of high blood pressure in the lungs. Researchers at the Stanford University School of...
Mount Sinai has partnered with Theragene Pharmaceuticals, Inc. to advance a novel airway-delivered gene therapy for treating pulmonary hypertension (PH), a form of high blood pressure in blood vessels in the lungs that is linked to heart failure. If the therapy succeeds in human clinical trials, it will provide patients for the first time with...
