by Delthia Ricks, Medical Xpress Lymphoid BLaER1 cells undergo PANX1-dominant lysis. (A to C) BLaER1 cells were treated with topoisomerase poisons doxorubicin (2 μM) or etoposide (50 μM) for 24 hours. Concurrent treatment with PANX1 inhibitor trovafloxacin (20 μM) or NLRP3 inflammasome inhibitor MCC950 (10 μM) were as indicated. In (A and C), quantification of...
by Liu Jia, Chinese Academy of Sciences A scanning electron microscope micrograph depicting a mass of Yersinia pestis bacteria in the foregut of an infected flea. Credit: Wikipedia Multiple strategies have been employed by pathogenic bacteria to sabotage host innate immune signaling to facilitate their infection. Previous studies revealed that the Yersinia effector protein YopJ targets and inhibits...
