Adam Oken, B.A., a graduate student in the Mansoor lab, points to a cryo-EM map (blue) and its corresponding model (mostly yellow and other colors). The cryo-EM map is generated after processing data obtained from the “advanced imaging techniques” and it directly corresponds to the position of atoms in 3D space. The assembly of thousands...
Tag: <span>receptors</span>
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Cellular traffic controllers caught managing flow of signals from receptors
UNIVERSITY OF BIRMINGHAM Proteins that act like air traffic controllers, managing the flow of signals in and out of human cells, have been observed for the first time with unprecedented detail using advanced microscopy techniques. Described in new research published today in Cell, an international team of researchers led by Professor Davide Calebiro from the University of Birmingham has...
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Ultraviolet B exposure expands proenkephalin+ regulatory T cells with a healing function
Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function NAGOYA CITY UNIVERSITY UVB IRRADIATION INDUCES PROLIFERATION AND ACTIVATION OF SKIN TREG CELLS. UVB-EXPANDED SKIN TREG (UVB-SKIN TREG) CELLS PROMOTE WOUND HEALING BY PRODUCING ENKEPHALIN AND AMPHIREGULIN(AREG), WHICH ENHANCE KERATINOCYTE GROWTH/PROLIFERATION TO REPAIR… view more CREDIT: DEPARTMENT IMMUNOLOGY, NAGOYA...
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Location, location, location: Even gut immune response is site-specific
by Julius-Maximilians-Universität Würzburg The pictures show the same stomach organoids: It shows the cell nuclei (blue) and the skeleton of the cell (pink) as a cross-section of the organoids. In grey is the microscopic picture of the organoids. A single organoid here is about a quarter millimeter in size. Credit: Julius-Maximilians-Universität Würzburg, JMU Why is...
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Researchers identify unique glucose-sensing neurons that regulate blood sugar
by Baylor College of Medicine Low blood sugar levels, known as hypoglycemia, can be a life-threatening situation, especially for people with type 1 diabetes who rely on intensive insulin therapy to prevent blood sugar from going too high. Solutions to this problem may come from a better understanding of the basic mechanisms keeping blood sugar...
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Drug that keeps surface receptors on cancer cells makes them more visible to immune cells
by Cell Press A drug that is already clinically available for the treatment of nausea and psychosis, called prochlorperazine (PCZ), inhibits the internalization of receptors on the surface of tumor cells, thereby increasing the ability of anticancer antibodies to bind to the receptors and mount more effective immune responses. PCZ enhanced the ability of anticancer...