by Elsevier Diagram of neuroinflammation in endometriosis. Researchers propose that IL-1β activates IL-1 type 1 membrane receptor (IL-1R1) in endometrial stromal cells, predominantly via the c-Jun N-terminal kinase (JNK) pathway, to promote neurotrophin and neurotrophin receptor (NTR) production and signaling, which in turn activate neurogenesis and pain. Parallel pathways promote IL-6 production and IL-1β autoregulation, potentially...
by Nina Bai, Stanford University Medical Center Graphical abstract. Credit: Journal of Clinical Investigation (2022). DOI: 10.1172/JCI163735 Stanford Medicine researchers have discovered a possible new way to treat pain without the use of opioids. By targeting a specific area of a well-known pain receptor, they were able to reduce pain sensitivity in mice without affecting the receptor’s other functions,...
Ultrasound works by sending sound waves through the body. Doctors can recommend ultrasound therapy to treat pain. It may work best alongside other treatments. Many people know ultrasound as an imaging tool that allows doctors to see inside the body. It can also be therapeutic, promoting tissue healing and treating pain. Both imaging and therapeutic...
by European Association of Urology Being immersed in a stunning ‘virtual’ Icelandic landscape can reduce the pain caused by uncomfortable medical procedures, new research has found. The study compared patients with and without virtual reality (VR) headsets having rigid cystoscopies, where a rigid telescope is inserted through the urethra into the bladder. The research is being presented today...
Knee osteoarthritis is a condition when the natural cushioning between knee joints (cartilage) wears away. Although it is commonly known as wear-and-tear arthritis, young people can get it too and it may even be hereditary. Knee osteoarthritis causes pain, which is usually addressed with paracetamol and nonsteroidal anti-inflammatory drugs. Now scientists from the University of...
