by International Society for Stem Cell Research A potentially alternative treatment for OA, a debilitating joint disease that affects more than 500 million people worldwide, is the regeneration of cartilage from stem cells. Learn more in Stem Cell Reports about the new work from Zhonghan Li and colleagues that focused on so-called limb bud progenitor...
By Dr. Liji Thomas, MDReviewed by Danielle Ellis, B.Sc. Mechanotherapy is an umbrella term for non-conventional physical therapy modalities that exploit mechanobiology principles for tissue rehabilitation and regeneration of tissues. It acts via the application of tailored mechanical forces. Image Credit: Ground Picture/Shutterstock.com While mechanical interventions have been used for thousands of years, scientists trace...
by Baker Heart & Diabetes Institute Pharmacological inhibition of EZH2 catalyzes pancreatic progenitor activation and β-cell maturation. The schematic outlines the progression from pancreatic multipotent progenitors to mature insulin-secreting β-cells, highlighting the regulatory target of EZH2 inhibitors, GSK126 and Tazemetostat. Credit: Signal Transduction and Targeted Therapy (2024). DOI: 10.1038/s41392-023-01707-xResearchers are zeroing in on the ultimate...
by University of Waterloo Cell sheets are guided to form anchored, scaffold-free constructs for in vitro modeling by providing pillars that act as anchors for otherwise anchorless cell sheets. Credit: Advanced Functional Materials (2023). DOI: 10.1002/adfm.202308552 People who have experienced significant muscle damage have new hope thanks to Evolved.Bio, a startup that has developed innovative technology...
by World Journal of Stem Cells Advantages of dental pulp stem cells as alternative stem cells for nerve regeneration. The figure was created with BioRender.com. DPSCs: Dental pulp stem cells. Credit: World Journal of Stem Cells (2023). DOI: 10.4252/wjsc.v15.i10.960 Peripheral nerve injury (PNI) seriously affects people’s quality of life. Stem cell therapy is considered a promising new...
by University of California – San Diego Neurons, shown here in red and yellow, are some of the slowest cells to regenerate after injury. In this section of a mouse brain, yellow neurons are regenerating while red neurons are non-regenerating. Credit: UC San Diego Health SciencesNeurons, the main cells that make up our brain and spinal...
By Michael Irving October 24, 2023 Scientists have found a new potential way to restore heart function after a heart attack, by reprogramming its energy metabolism Depositphotos Most tissues in the body can regenerate themselves after an injury, but unfortunately heart muscle cells aren’t one of them. Now, scientists at the Max Planck Institute have shown...
by Weill Cornell Medical College Graphical abstract. Credit: Cell Stem Cell (2022). DOI: 10.1016/j.stem.2022.03.002 Researchers at Weill Cornell Medicine have identified a key protein that induces the program to build specialized liver blood vessels. The discovery could lead to engineered replacement hepatic tissue to treat common liver diseases. There are many types of blood vessels in the human...
by Max Planck Society Impaired repair of chronic lesions in neuronal cholesterol mutants (NcKO). The mutants form less myelin (brown), and the proliferation of oligodendrocytes (green) is reduced. Credit: MPI for Experimental Medicine/ Berghoff The degradation and regeneration of myelin sheaths characterize neurological disorders such as multiple sclerosis. Cholesterol is an indispensable component of myelin...
by UT Southwestern Medical Center Liver lobule structure, identifying the three zones. Credit: UT Southwestern Medical Center While the amazing regenerative power of the liver has been known since ancient times, the cells responsible for maintaining and replenishing the liver have remained a mystery. Now, research from the Children’s Medical Center Research Institute at UT Southwestern (CRI) has identified the...
