by Texas Children’s Hospital The molecular regulation of Wnt signaling in the OL lineage by Daam2 phosphorylation. The activity of Daam2-mediated Wnt signaling is low in OPCs and early OLs (Left) but upregulated in mature OLs (Middle). When ligands trigger Wnt signaling, the destruction complex is inhibited, allowing β-catenin to enter the nucleus where it...
by Duke-NUS Medical School Vascularization of human muscle grafts. a Schematic illustration of: (i) CCP generation; (ii) permanent MI infarction; (iii) intramyocardial transplantation of CCP; (iv) post-transplantation MRI and CT scans, and (v) euthanization at 4 or 12 weeks post-transplantation. At 4 weeks, the human grafts showed disorganized staining of b TNNT2 (red) Scale bar = 20 μm, d ACTN2 (red) and MLC2v...
By Dr. Sanchari Sinha Dutta, Ph.D. Reviewed by Danielle Ellis, B.Sc. Erectile dysfunction is a common sexual abnormality in men. The condition is characterized by the inability to get or keep an erection during sexual activity. New regenerative therapies have shown promising outcomes in restoring the structure and function of affected erectile tissues. Image Credit:...
by Zach Winn, Massachusetts Institute of Technology These images show cellular regeneration, in pink, in a preclinical model of sensorineural hearing loss. The control is on the left and the right has been treated. Credit: Hinton AS, Yang-Hood A, Schrader AD, Loose C, Ohlemiller KK, McLean WJ Most of us know someone affected by hearing...
by Paul Tumarkin, University of Arizona Roberta Diaz Brinton. Credit: Photo courtesy of Tech Launch Arizona and NeuTherapeutics University of Arizona researchers have developed a new therapy for Alzheimer’s disease designed to restore cognitive function in early-stage patients. The therapy is now proceeding through a Phase 2b clinical trial. Phase 2b trials involve rigorous testing for efficacy in...
A detour on the road to regenerative medicine for people with muscular disorders is figuring out how to coax muscle stem cells to fuse together and form functioning skeletal muscle tissues. A study published June 1 by Nature Communications reports scientists identify a new gene essential to this process, shedding new light on possible new therapeutic strategies....
