by Melissa Rohman, Northwestern University Muller’s lab recently demonstrated that calcium flux in endothelial cells is tightly coupled temporally and spatially with leukocyte transmigration. The arrows depict local elevation of [Ca2+]i (green) at endothelial junctions (blue) as neutrophils (red) transmigrate across a postcapillary venule in the mouse cremaster muscle in response to the inflammatory cytokine,...
