by Ellen Goldbaum, University at Buffalo The inflamed tissue environment following demyelination prevents recruitment of oligodendrocyte progenitor cells (OPC) (green) and halts their division (red). This can be overcome by treatment with PI-88, a modulator of the heparanome (Credit: Darpan Saraswat Two papers by University at Buffalo researchers reveal important new findings as to how regeneration of myelin...
A new study shows that when specific human brain cells are transplanted into animal models of multiple sclerosis and other white matter diseases, the cells repair damage and restore function. The study provides one of the final pieces of scientific evidence necessary to advance this treatment strategy to clinical trials. “These findings demonstrate that through...
July 17, 2018 by Ellen Goldbaum, University at Buffalo Remyelination, the spontaneous regeneration of the fatty insulator in the brain that keeps neurons communicating, has long been seen as crucial to the next big advance in treating multiple sclerosis (MS). However, a lack of understanding of how remyelination is stymied in the disease has hampered these...
