Tag: <span>Rescues Parkinsonian Phenotypes</span>

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Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo

Highlights Cryopreserved human iPSC-mDA neurons retain high viability and midbrain lineage iPSC-mDA neurons secrete dopamine and possess typical electrophysiological parameters Grafted iPSC-mDA neurons survive and innervate rodent and monkey PD models Cryopreserved iPSC-mDA neurons reverse functional motor deficits in 6-OHDA rats Summary A major challenge for clinical application of pluripotent stem cell therapy for Parkinson’s...