August 8, 2024 by Samuel Hanegreefs, Leiden University Unsplash/CC0 Public Domain Science Translational Medicine has published a study by researchers from the Institute of Biology Leiden (IBL) on a potent new antibiotic that can overcome resistance. “The idea was to tweak the original antibiotic and create a next-generation drug,” says Nathaniel Martin, professor of Biological...
Tag: <span>resistance</span>
A breast cancer drug, susceptible to resistance, can be restored to effectiveness, researchers demonstrate
by Leslie Cantu, Medical University of South Carolina Credit: Pixabay/CC0 Public Domain In a new paper published in Cancer Research, researchers at MUSC Hollings Cancer Center have shown that targeting a protein called TACC3 (transforming acidic coiled-coil containing protein 3) can restore the effectiveness of the breast cancer drug T-DM1 if the cancer cells have developed...
New drug reveals a key mechanism to overcome resistance to protein degraders
Peer-Reviewed Publication INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA) Barcelona, 30 January 2024 – Protein degraders, a novel approach in drug discovery, show promise to tackle diseases previously thought to be untreatable. Unlike traditional drugs that block specific protein functions, degraders alter the cell’s natural degradation process so that it can remove disease-relevant proteins. However,...