by Justin Jackson, Medical Xpress Oral mucosal breaks trigger systemic inflammatory responses.(A) Experimental workflow. (B) Inferred relative bacterial abundances from eight HMP body sites (n = 336). (C) Body site–inferred relative abundances for time points from RA patients with and without periodontal disease, median. (D) Inferred relative oral abundances in blood for one RA donor with and...
by RIKEN Enrichment of high PIP variants within open chromatin regions of 18 blood cell populations was analyzed by gchromVAR software. The horizontal dashed line indicates Bonferroni corrected P value threshold (0.05/18 = 0.0027). P values were estimated by the enrichment test implemented in gchromVAR. Credit: Nature Genetics (2022). DOI: 10.1038/s41588-022-01213-w In a large genetic study published in Nature Genetics,...
by Liu Jia, Chinese Academy of Sciences Schematic illustration of the fabrication process of the designed dual-triggered theranostics nanoprobe and the high-sensitivity autofluorescence-free imaging-guided RA treatment and therapeutic evaluation. Credit: Advanced Science (2022). DOI: 10.1002/advs.202205320 Rheumatoid arthritis (RA), known as “immortal cancer,” is a chronic, progressive autoimmune inflammatory disease. The development and application of an RA high-sensitivity...
ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY(UNIST) IMAGE: PROFESSOR SUNG HO PARK (CENTER) AND HIS RESEARCH TEAM IN THE DEPARTMENT OF BIOLOGICAL SCIENCES AT UNIST. CREDIT: UNIST A research team, led by Professor Sung Ho Park in the Department of Biological Sciences at UNIST announced the results of a study on osteoblasts that damage joint bones in patients...
by Lori Solomon There may be an association between rheumatoid arthritis (RA) and peripheral artery disease (PAD), according to a review published online Nov. 30 in Rheumatology International. Tayser Zoubi, from Flinders University in Adelaide, Australia, and Hendry Gordon, Ph.D., from Glasgow Caledonian University in the United Kingdom, conducted a systematic literature review to examine the...
by European Alliance of Associations for Rheumatology (EULAR) Flow chart. ACR, American College of Rheumatology; bDMARDs, biological disease-modifying antirheumatic drugs; csDMARDs, conventional synthetic DMARDs; FDA, Food and Drug Administration; JAK, Janus kinase; MTX, methotrexate; NMSC, non-melanoma skin caner; tsDMARDs, targeted synthetic DMARDs. Credit: Annals of the Rheumatic Diseases (2022). DOI: 10.1136/ard-2022-223356 Since their first publication...
by University of California – San Diego An x-ray depicts a hand fully affected by rheumatoid arthritis, which is characterized by swollen, painful joints, most commonly involving the wrists and hands. Credit: Wikimedia Using a novel systems biology approach, scientists at University of California San Diego School of Medicine have further parsed the cellular players...
By Rich Haridy October 19, 2022 New research speculates immune antibodies targeting a gut bacteria protein could play a role in the development of rheumatoid arthritis Depositphotos A study published in the journal Arthritis & Rheumatology has provided new evidence gut bacteria plays a role in the development of rheumatoid arthritis. The research suggests an abnormal immune...
WILEY Rheumatoid arthritis is a chronic autoimmune disease that is associated with aberrant immune responses. In a recent analysis published in Arthritis & Rheumatology, people at risk for rheumatoid arthritis (RA) and those with the disease had elevated blood levels of antibodies against a bacterial protein that’s normally found in the body. The study compared 98...
by National Jewish Health Credit: Pixabay/CC0 Public Domain For the first time, researchers have shown that a class of anti-fibrotic drugs slows the progression of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA). Research conducted in part at National Jewish Health showed that pirfenidone was safe and effective in these patients. The study,...
