by Eva Maria Wellnitz, Universitätsmedizin Mannheim Graphical Abstract. Credit: Immunity (2023). DOI: 10.1016/j.immuni.2023.03.021 A team of international scientists led by the Heidelberg University, Medical Faculty Mannheim, and the Newcastle University (Great Britain) has succeeded in decoding a new mechanism of immune cell trafficking by examining vascular diseases. Surprisingly, the fine-tuning of this fundamental immune defense process is...
UNIVERSITY OF CALIFORNIA – SAN DIEGO New research led by bioengineers at the University of California San Diego could make it much simpler to repair disease-causing mutations in RNA without compromising precision or efficiency. The new RNA editing technology holds promise as a gene therapy for treating genetic diseases. In a proof of concept, UC...
Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells. Fusing an RNA-editing enzyme to an RNA-targeting Cas protein has enabled researchers to edit specific nucleotides within RNA molecules in human cells. The approach, called RNA Editing for Programmable A-to-I replacement (REPAIR), is described today (October 25)...
