by Frontiers Journals Credit: Frontiers of Medicine (2024). DOI: 10.1007/s11684-024-1064-8 Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications. A comprehensive review published in Frontiers of Medicine reveals the significant role of various RNA modifications in cancer development and progression. The review particularly focuses...
Tag: <span>RNA modification</span>
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RNA modification ‘pivotal’ for protein linked to neurodegeneration in ALS
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN Nearly 100% of cases of amyotrophic lateral sclerosis—the progressive, fatal neurodegenerative disease known as ALS or Lou Gherig’s disease — involve the buildup of a protein called TDP-43. Scientists know that TDP-43, which helps regulate processing of RNA, may be responsible for the death of nerve cells in ALS...
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RNA modification may protect against liver disease
by University of California, Los Angeles Schematic representation of m6A modifications (blue) attaching to RNA in the liver. Credit: Sallam Lab/UCLA A chemical modification that occurs in some RNA molecules as they carry genetic instructions from DNA to cells’ protein-making machinery may offer protection against non-alcoholic fatty liver, a condition that results from a build-up of...