By Dr. Surat P, Ph.D. Reviewed by Michael Greenwood, M.Sc. Enhancer RNAs, or eRNAs, are short non-coding RNA molecules that are transcribed from the loci of enhancers. They are involved in the regulation of gene transcription and can be a therapeutic target for diseases. Enhancer RNAs were discovered in 2010 through high-throughput sequencing to detect stimulus-dependent enhancers. This revealed the RNApolymerase II-dependent transcription of enhancer RNAs. These are...
Tag: <span>RNA polymerase</span>
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Study reveals how enzyme detects ultraviolet light damage
Damage to DNA is a constant threat to cellular life, and so it is constantly monitored and detected by a family of enzymes called RNA polymerases, resulting in subsequent repair to maintain genome integrity. In a paper published this week in the journal PNAS, researchers at University of California San Diego School of Medicine, with colleagues in Spain...
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New antibiotic effective against drug-resistant bacteria
First selective nucleoside-analog inhibitor of bacterial RNA polymerase Structure of bacterial RNA polymerase, showing the binding sites for the new antibiotic pseudouridimycin (PUM) and the current antibacterial drug rifampin (Rif). PUM has a lower resistance rate and a smaller resistance target than Rif — just 2 to 4 positions where alterations that result in PUM-resistance...