by The Hospital for Sick Children Cis-acting elements in the 3ʹUTR are highly associated with half-life changes. a Random forest classifier for prediction of mRNA sequence features relevant for half-life fold-change in human NEURTT and in cortical brain samples of the mouse Mecp2 y/-. Percent accuracy (Y-axis) of half-life fold-change predictions in human NEURTT (b) from 2 replicates or...
LUND UNIVERSITY Researchers at Lund University Faculty of Medicine have determined a novel mechanism linking the metabolism of ribonucleic acids, RNA, to the development of leukemia in myelodysplastic syndrome patients, MDS. In a study published in the Molecular Cell journal, they explain what makes hematopoietic stem cells acquire malignant traits in cancer. RNA splicing is a major...
by Hudson Institute of Medical Research Credit: Hudson Institute of Medical Research A new insight into RNA regulation has taken researchers a big step forward in understanding how the body creates platelets. Platelets are the smallest of all blood cells; they circulate in the bloodstream and bind together when they recognize damaged blood vessels, making them a...
By Michael Dhar published October 15, 2020 This flexible molecule tells the cell’s protein-making factories what DNA wants them to do, stores genetic information and may have helped life get its start. Artist’s interpretation of a strand of RNA. (Image credit: Shutterstock) More than just DNA’s lesser-known cousin, RNA plays a central role in turning genetic information into your...
by Massachusetts Institute of Technology Credit: CC0 Public Domain Like most vaccines, RNA vaccines have to be injected, which can be an obstacle for people who fear needles. Now, a team of MIT researchers has developed a way to deliver RNA in a capsule that can be swallowed, which they hope could help make people...
by Elsevier Bubbler kits were processed in a negative pressure bench top box to prevent contamination of amplicon particles in the laboratory. Credit: William G. Fairbrother In a new study in The Journal of Molecular Diagnostics, investigators report on the design and testing of a breathalyzer, known as the Bubbler, that relies on viral RNA detection to...
by Ecole Polytechnique Federale de Lausanne Credit: CC0 Public Domain In a joint, collaborative effort between laboratories at EPFL, NTNU Norway, and CBMR Denmark, researchers examined the molecular effect of exercise upon noncoding RNA genes in skeletal muscle in Science Translational Medicine. In this study, they discovered the long noncoding RNA “CYTOR” and investigated its...
Investors flock to biotech startup Orna Therapeutics on the promise of low-cost treatment. By Angelica LaVito ILLUSTRATION: FATCHUROFI MUHAMMAD FOR BLOOMBERG BUSINESSWEEK Less than two years ago, most people had never heard of mRNA. Then came the pandemic, and the scientific term became a household word. Now, Moderna Inc. and BioNTech SE are on the verge of selling more...
by Monash University Graphical abstract. Credit: DOI: 10.1016/j.devcel.2021.07.021 New research from the Australian Regenerative Medicine Institute (ARMI) at Monash University has identified novel cell types and RNA signals that may assist with brain and spinal cord repair. Tissues and organs have different capacities to regenerate after injury or disease. Identifying cell types and signals that can promote repair is particularly...
The Centers for Disease Control and Prevention (CDC) has been examining the real-world performance of the two vaccines since they were first authorized among health care personnel, first responders and other frontline workers. The effectiveness against infection of the Pfizer and Moderna COVID-19 vaccines dropped from 91 percent before the Delta variant became dominant to...
