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Fixing Rogue Brain Cells May Hold Key to Preventing Neurodegeneration
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Fixing Rogue Brain Cells May Hold Key to Preventing Neurodegeneration

A team led by scientists at Case Western Reserve University School of Medicine has identified a new therapeutic approach for combating neurodegenerative diseases, offering hope of improved treatments for Alzheimer’s disease, Parkinson’s disease, Vanishing White Matter disease and multiple sclerosis, among others.Astrocytes. Astrocytes. Image credit: CWRU Neurodegenerative diseases, which affect millions of people worldwide, occur...

Fixing rogue brain cells may hold key to preventing neurodegeneration
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Fixing rogue brain cells may hold key to preventing neurodegeneration

by Case Western Reserve University Phenotypic screen identifies HDAC3 as a regulator of pathological reactive astrocytes. a, Scatter plot of primary screen results displayed as percent GBP2 positive, normalized to reactive astrocyte plus vehicle controls for all nontoxic chemicals. Validated hit chemicals colored in blue. The dashed blue line represents the hit cut-off at a ≥90%...