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Researchers uncover why cells struggle to fully change identity in reprogramming efforts

News Release 19-Sep-2024 Peer-Reviewed PublicationThe Hebrew University of Jerusalem A new study reveals that reprogramming specialized cells to become different types of cells, a key process in regenerative medicine, faces a major hurdle. The challenge lies in the DNA methylation patterns of the cells, which are like cellular “memory” markers. This study reveals that these...

Researchers decipher new molecular mechanisms related to biological tissue regeneration
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Researchers decipher new molecular mechanisms related to biological tissue regeneration

News Release 29-Jul-2024 Drosophila: a model for studying human diseases Peer-Reviewed PublicationUniversity of Barcelona image: From left to right, experts Florenci Serras, research leader, and José Esteban-Collado, first author of the article. Credit: UNIVERSITY OF BARCELONA A study lead by the University of Barcelona opens new perspectives to better understand how the molecular mechanisms involved...

Molecular targets of microRNAs during liver regeneration after acute injury: Recent advances
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Molecular targets of microRNAs during liver regeneration after acute injury: Recent advances

News Release 29-Jul-2024 Peer-Reviewed PublicationXia & He Publishing Inc. image: Upregulation of miR21 during APAP hepatotoxicity inhibits hepatocyte proliferation by downregulating the β-catenin signaling pathway. Additionally, miR21 overexpression affects liver repair by inducing changes in gene expression, leading to the downregulation of autophagy and haemostasis. APAP, acetaminophen. The liver, a vital organ involved in numerous...

New study shows ‘dancing molecules’ can regenerate cartilage in 3 days
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New study shows ‘dancing molecules’ can regenerate cartilage in 3 days

by Amanda Morris, Northwestern University Cartilage cells generate more protein components (collagen II and aggrecan) for regeneration when treated with fast-moving dancing molecules (left) compared to slower moving molecules. Credit: Stupp Research Group/Northwestern UniversityIn November 2021, Northwestern University researchers introduced an injectable new therapy, which harnessed fast-moving “dancing molecules,” to repair tissues and reverse paralysis...

Cardiomyocytes study discovers new way to regenerate damaged heart cells
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Cardiomyocytes study discovers new way to regenerate damaged heart cells

MAY 31, 2024 by Olivia Dimmer, Northwestern University Credit: Unsplash/CC0 Public Domain Northwestern Medicine scientists have discovered a way to regenerate damaged heart muscle cells in mice, a development that may provide a new avenue for treating congenital heart defects in children and heart attack damage in adults, according to a study published in the...