by Delthia Ricks, Medical Xpress SARS-CoV-2 S protein evolution was used to guide the design of the Span sequence.(A) Phylogenetic trees are shown for 2675 S protein amino acid sequences from the NCBI database. (B) Proportion of the top five mutations and the E484K mutation for the amino acid sequences analyzed. (C) Linear diagram of the...
by Instituto de Medicina Molecular Grphical abstract. Credit: ACS Central Science (2023). DOI: 10.1021/acscentsci.2c01243 A new study led by Gonçalo Bernardes, group leader at the Instituto de Medicina Molecular João Lobo Antunes (iMM; Portugal) and Professor at the University of Cambridge (Cambridge, UK), published recently in the journal ACS Central Science, reports the discovery of a compound efficient...
by Kelly Malcom, University of Michigan Credit: Cell Reports Medicine (2022). DOI: 10.1016/j.xcrm.2022.100774 On January 13, 2020, a paper touting the creation of a possible therapy that could be used to fight all known strains of the flu was published online. One week later, the first laboratory-confirmed case of SARS-CoV-2 set off the 2.5 year-long COVID-19 pandemic...
by Marla Paul, Northwestern University Graphical abstract. Credit: Journal of Clinical Investigation (2022). DOI: 10.1172/JCI162282 An entirely new approach to monoclonal antibody therapy shows that targeting the more genetically stable internal protein of the SARS-CoV-2 virus rather than the surface spike protein can also clear SARS-CoV-2, reports a study from Northwestern Medicine and the University of Illinois...
by Karina Toledo, FAPESP Research by groups at the University of São Paulo and the State University of Campinas combined MRI scans of the brains of mild COVID-19 patients, analysis of brain tissue from people who died of the disease and experiments on human nerve cells infected in the laboratory. Image demonstrating cortical thickness atrophy in...
by CIC bioGUNE Proteomic analyses reveal changes in hACE2 mouse hepatocytes after infection with pseudotyped viral particles expressing the spike of SARS-CoV-2. a Volcano plot showing the 354 differentially expressed peptides between hACE2 mouse hepatocytes in the presence (+) or absence (−) of pseudotyped viral particles after 48 h. b Volcano plot showing the 132 differentially...
by Children’s Hospital Boston Credit: Unsplash/CC0 Public Domain As SARS-CoV-2 has evolved and mutated, therapeutic antibodies that worked early in the pandemic have become less effective, and newer variants, especially omicron, have developed ways to evade the antibodies we make in response to vaccines. A new, broadly neutralizing antibody developed at Boston Children’s Hospital could potentially...
by Cardiff University Credit: Cardiff University U.K. scientists have highlighted a mutation in the spike protein of SARS-CoV-2 that allows the virus to evade important immune cells induced by infection and vaccines. The P272L Spike mutation first arose during the U.K.’s second wave of COVID-19, which began in September 2020, and has been pinpointed to...
JULY 28TH, 2022 CONN HASTINGS MATERIALS, NEWS, PUBLIC HEALTH Researchers at the University of Kentucky created a novel membrane that can enzymatically degrade the SARS-CoV-2 spike protein, rendering the virus inactive. The membrane is intended to act as an insert within face masks, providing extra protection for groups at high risk of SARS-CoV-2 exposure, such as...
by AIDS Clinical Trials Group Credit: Unsplash/CC0 Public Domain The AIDS Clinical Trials Group (ACTG), the largest global HIV research network, which expanded to conduct research into COVID-19, today announced the publication of “Monoclonal Antibody Treatment Drives Rapid Culture Conversion in SARS-CoV-2 Infection,” in the journal Cell Reports Medicine. The publication reports on findings from the...
