by Washington University in St. Louis Scientists at Washington University School of Medicine in St. Louis have developed a compound that prevents SARS-CoV-2 and related coronaviruses from entering cells. The researchers are collaborating with the National Institutes of Health (NIH) to test the compound in animal models of COVID-19. Pictured is the compound, called MM3122, (yellow) blocking the...
Tag: <span>SARS-CoV-2</span>
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Newly generated monoclonal antibodies effective against SARS-CoV-2 and variants
by Kumamoto University The 9-105 antibody neutralizes SARS-CoV-2 completely by binding to vulnerable sites on the spike protein. It even blocks viral replication at low concentrations. Credit: Kumamoto University Japanese researchers have successfully produced potent neutralizing monoclonal antibodies from a patient who recovered rapidly from a severe case of COVID-19. In addition to appearing to have the world’s...
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Scientists discover a highly potent antibody against SARS-CoV-2
ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE The newly identified antibody was isolated using lymphocytes from COVID-19 patients enrolled in the ImmunoCoV study being carried out by CHUV’s Service of Immunology and Allergy. This antibody is one of the most powerful identified so far against SARS-CoV-2. Structural characterization of the antibody indicates that it binds to an...
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Mitigating lung damage, mortality due to SARS-CoV-2
by University of Illinois at Chicago Figure 1. SARS-CoV-2 infection activates lung NLRP3–CASP (caspase)-1 inflammatory signaling and lung inflammation in K18-ACE-2 mice. K18-hACE-2 humanized mice (2 mo old) were inoculated with SARS-CoV-2 (1×105 p.f.u.) for 2 and 7 d. A, Expression of NLRP3 inflammasome, cleavage of CASP-1/11, IL (interleukin)-1β maturation, and CREB and VE-cadherin expression in...
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For unvaccinated, reinfection by SARS-CoV-2 is likely, study finds
By Michael Greenwood Throughout the COVID-19 pandemic, there has been much uncertainty about how long immunity lasts after an unvaccinated person is infected with SARS-CoV-2. Now a team of scientists led by faculty at Yale School of Public Health and the University of North Carolina at Charlotte have an answer: Strong protection following natural infection...
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Scientists investigate how infection by SARS-CoV-2 can lead to kidney disorders
IMAGE: LOSS OF ACE2 LEADS TO AN IMBALANCE IN SYSTEMS THAT REGULATE ESSENTIAL METABOLIC FUNCTIONS, IMPAIRING BLOOD FILTRATION AND CAUSING KIDNEY INJURIES THAT CAN BECOME PERMANENT CREDIT: HOLLY FISCHER/HOLLY FISCHER/WIKIMEDIA COMMONS HTTPS://COMMONS.WIKIMEDIA.ORG/WIKI/FILE:KIDNEY_CROSS_SECTION.PNG A review article published in the journal Frontiers in Physiology by researchers affiliated with the Federal University of São Paulo (UNIFESP) in Brazil discusses the mechanisms whereby SARS-CoV-2...
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Scientists investigate how infection by SARS-CoV-2 can lead to kidney disorders
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO IMAGE: LOSS OF ACE2 LEADS TO AN IMBALANCE IN SYSTEMS THAT REGULATE ESSENTIAL METABOLIC FUNCTIONS, IMPAIRING BLOOD FILTRATION AND CAUSING KIDNEY INJURIES THAT CAN BECOME PERMANENT CREDIT: HOLLY FISCHER/HOLLY FISCHER/WIKIMEDIA COMMONS HTTPS://COMMONS.WIKIMEDIA.ORG/WIKI/FILE:KIDNEY_CROSS_SECTION.PNG A review article published in the journal Frontiers in Physiology by researchers affiliated with the Federal University of...
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Long COVID symptoms in children rarely persist beyond 12 weeks
by Murdoch Children’s Research Institute Credit: Unsplash/CC0 Public Domain Long COVID symptoms rarely persisted beyond 12 weeks in children and adolescents unlike adults. But more studies were required to investigate the risk and impact of long COVID in young people to help guide vaccine policy decisions in Australia, according to a review led by the Murdoch...
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Drugs that mimic effects of cigarette smoke reduce SARS-CoV-2’s ability to enter cells
by Hiroshima University A team of Japanese scientists demonstrates that treatment with AHR agonists decreases expression of ACE2 via AHR activation, resulting in suppression of COVID-19. Credit: DBCLS TogoTV / CC-BY-4.0 Researchers have identified a potential reason why lower numbers of COVID cases have appeared amongst smokers compared to non-smokers, even as other reports suggest smoking increases...
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Mu SARS-CoV-2 variant highly resistant to neutralization by convalescent and vaccinated sera
Researchers in Japan have warned that the Mu (B.1.621) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – appears to be highly resistant to neutralization by sera from convalescent or vaccinated individuals. The B.1.621 variant, first isolated in Colombia in January this year (2021), was classified...