Tag: <span>SASP</span>

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A Short Tour of the Senescence-Associated Secretory Phenotype
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A Short Tour of the Senescence-Associated Secretory Phenotype

Senescent cells accumulate with age, but are never more than a tiny fraction of somatic cells in most tissues, even in very late life. Senescent cells nonetheless cause considerable harm via the signals that they produce, the senescence-associated secretory phenotype (SASP). These signals provoke chronic inflammation, harmful remodeling of tissue, and dysfunctional activity in nearby cells. That comparatively few senescent cells...