by Karolinska Institutet Cerebrospinal fluid levels of C4A are increased in patients with first-episode psychosis who develop schizophrenia. a Overview of the study design. b In the discovery cohort (KaSP), patients with first-episode psychosis (FEP) who developed schizophrenia (FEP-SCZ; n = 29) displayed significantly higher cerebrospinal fluid (CSF) C4A concentrations as compared to healthy controls (HCs; n = 20)...
LIEBER INSTITUTE FOR BRAIN DEVELOPMENT Baltimore, Md. (November 1, 2022) – Researchers at the Lieber Institute for Brain Development(LIBD) believe they have solved a riddle that has challenged scientists for more than 70 years: how the brain chemical dopamine relates to schizophrenia, the often-devastating brain disorder characterized by delusional thinking, hallucinations and other forms of psychosis. Through...
UNIVERSITY OF COPENHAGEN – THE FACULTY OF HEALTH AND MEDICAL SCIENCES If you thought it was easy to analyse brain cells, think again. When you take a brain tissue sample, all that your analysis would normally show you is an average for all the cell types present. And since there is a whole lot of...
by University College Dublin Credit: Pixabay/CC0 Public Domain The risk of schizophrenia and bipolar disorder may be detectable years before the illnesses begin, according to new research. A University College Dublin led study funded by the Health Research Board has found that 50% of people who developed these mental health disorders had attended specialist child and adolescent...
Schizophrenia is a fairly uncommon condition, affecting around 0.25–0.64% of people in the United States. It can have a profound impact on a person’s life, as well as the lives of those around them. Schizophrenia is a lifelong condition, but treatment can help manage the symptoms. This article will look at the causes and symptoms...
by DGIST (Daegu Gyeongbuk Institute of Science and Technology) Credit: Pixabay/CC0 Public Domain A joint research team of Daegu Gyeongbuk Institute of Science and Technology professors Um Ji-won and Ko Jae-won of the Department of Brain Sciences reported a new genetic mutation related to intellectual disability and discovered an excitatory synaptic activation signaling mechanism related...
by Anke Schlee, Max Planck Society Neuroanatomical patterns of schizophrenia. Credit: Koutsouleris Researchers have, for the first time, compared schizophrenia and frontotemporal dementia—disorders that are both located in the frontal and temporal lobe regions of the brain. The idea can be traced back to Emil Kraepelin, who coined the term “dementia praecox” in 1899 to describe...
by Tokyo Medical and Dental University NCAM1 is induced only in green cells (HeLa cells). Serum from patients with anti-NCAM1 autoantibody react only to green cells (framed in red). Credit: Department of Psychiatry and Behavioral Sciences, TMDU Schizophrenia is a disorder that affects how people act, think, and perceive reality. It is often very difficult...
Researchers at Tel Aviv University (TAU) have unraveled a mechanism shared by mutations in the genes ADNP and SHANK3, which cause autism, schizophrenia, and other conditions. The researchers also found that an experimental drug previously developed in their lab is effective in lab models for these mutations and may be suitable for treating a range of rare syndromes...
Lithium’s main treatment for bipolar disorder was approved a half-century ago but didn’t help all patients and has significant side effects. In part, little progress has been made in finding better therapies because scientists don’t fully understand how the condition arises or exactly how lithium improves symptoms when it does work. A genetic study involving...
