(HealthDay)—Cognitive remediation is effective for both cognitive and functional outcomes among patients with schizophrenia, according to a systematic review and meta-analysis published in the August issue of JAMA Psychiatry. Antonio Vita, M.D., Ph.D., from the University of Brescia in Italy, and colleagues conducted a systematic literature review to identify randomized clinical trials comparing cognitive remediation to any other...
by Zhang Nannan, Chinese Academy of Sciences Credit: CC0 Public Domain Schizophrenia is a neurodevelopmental disorder characterized by both brain structural and functional abnormalities. Most of the existing findings, however, were limited to adult patients with established schizophrenia with a long duration of illness. It is still not clear whether the altered brain structural and functional...
by Patty Shillington, University of Massachusetts Amherst Researchers created neurons from cell specimens donated by schizophrenia patients with a rare genetic mutation. Credit: UMass Amherst A scientific team has shown that the release of neurotransmitters in the brain is impaired in patients with schizophrenia who have a rare, single-gene mutation known to predispose people to a range...
IMPACT JOURNALS LLC Oncotarget published “The presence of polymorphisms in genes controlling neurotransmitter metabolism and disease prognosis in patients with prostate cancer: a possible link with schizophrenia” reported that polymorphisms of neurotransmitter metabolism genes were studied in patients with prostate cancer (PC) characterized by either reduced or extended serum prostate-specific antigen doubling time corresponding to unfavorable...
COLUMBIA UNIVERSITY IRVING MEDICAL CENTER Adults with schizophrenia have an elevated risk of dying from suicide. Yet there’s only limited understanding of when and why people with schizophrenia die of suicide –in part because research studies have looked at relatively small groups of patients. Now a new study from Columbia that looked at a large...
by Will Doss, Northwestern University Neurons in the prefrontal cortex of mice modeling cognitive impairment in schizophrenia (scPCP model, right panel) show increased expression of NKCC1 transcript (dark dots) compared to control animals (left panel). Credit: Northwestern University Alterations in the balance of two chloride ion transporters may be responsible for cognitive deficits in schizophrenia, according...
UNIVERSITY OF PENNSYLVANIA IMAGE: A GENETIC CONDITION KNOWN AS 22Q.11.2 DELETION SYNDROME IS ASSOCIATED WITH AN INCREASED RISK OF SCHIZOPHRENIA. A PENN VET-LED TEAM FOUND THAT A LEAKY BLOOD-BRAIN BARRIER, ALLOWING INAPPROPRIATE IMMUNE INVOLVEMENT CREDIT: COURTESY OF JORGE IVÁN ALVAREZ Like a stern bodyguard for the central nervous sytem, the blood-brain barrier keeps out anything...
by Tim Pilgrim, Brunel University Functional magnetic resonance imaging (fMRI) and other brain imaging technologies allow for the study of differences in brain activity in people diagnosed with schizophrenia. The image shows two levels of the brain, with areas that were more active in healthy controls than in schizophrenia patients shown in orange, during an fMRI...
by NYU Langone Health Functional magnetic resonance imaging (fMRI) and other brain imaging technologies allow for the study of differences in brain activity in people diagnosed with schizophrenia. The image shows two levels of the brain, with areas that were more active in healthy controls than in schizophrenia patients shown in orange, during an fMRI study...
UNIVERSITY OF TURKU A new study conducted at the University of Turku, Finland, shows that patients with a schizophrenia spectrum disorder have an increased risk of Parkinson’s disease later in life. The increased risk may be due to alterations in the brain’s dopamine system caused by dopamine receptor antagonists or neurobiological effects of schizophrenia. The...
