by Wendy Bindeman , Vanderbilt University Credit: Pixabay/CC0 Public Domain A new study led by Jeff Conn, Lee E. Limbird Chair in Pharmacology, James Maksymetz, a former graduate student in the Conn laboratory, and other collaborators at the Warren Center for Neuroscience Drug Discovery has identified a protein in the central nervous system, known as...
by University of Surrey Typical rhythms of sleep, activity and light exposure. (a), (d): Light (yellow trace), activity (gray trace), 6-sulphatoxymelatonin (aMT6s) acrophase (red circles) and sleep timing (horizontal gray bars). (b) and (e): Average pattern of light exposure across the 24-h day. The shaded regions from white through to dark gray indicate the fraction of...
by Elsevier rsEEG results, DCM model structure, and rsEEG simulations. A – The mean normalized eyes closed and eyes open rsEEG power spectra (±s.e.m.) across all channels for Con (n=98; blue) and PScz (n=95; red) groups, divided into four frequency bands (dotted lines): θ (3-7 Hz), α (8-14 Hz), β (15-30 Hz) and γ (>31...
THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE With the help of cutting-edge computer programs, researchers at the Icahn School of Medicine at Mount Sinai went through the genetic and medical records of more than 8,000 schizophrenia patients. They found that a tool commonly used in research for evaluating a person’s genetic risk...
(HealthDay)—Cognitive remediation is effective for both cognitive and functional outcomes among patients with schizophrenia, according to a systematic review and meta-analysis published in the August issue of JAMA Psychiatry. Antonio Vita, M.D., Ph.D., from the University of Brescia in Italy, and colleagues conducted a systematic literature review to identify randomized clinical trials comparing cognitive remediation to any other...
by Zhang Nannan, Chinese Academy of Sciences Credit: CC0 Public Domain Schizophrenia is a neurodevelopmental disorder characterized by both brain structural and functional abnormalities. Most of the existing findings, however, were limited to adult patients with established schizophrenia with a long duration of illness. It is still not clear whether the altered brain structural and functional...
by Patty Shillington, University of Massachusetts Amherst Researchers created neurons from cell specimens donated by schizophrenia patients with a rare genetic mutation. Credit: UMass Amherst A scientific team has shown that the release of neurotransmitters in the brain is impaired in patients with schizophrenia who have a rare, single-gene mutation known to predispose people to a range...
IMPACT JOURNALS LLC Oncotarget published “The presence of polymorphisms in genes controlling neurotransmitter metabolism and disease prognosis in patients with prostate cancer: a possible link with schizophrenia” reported that polymorphisms of neurotransmitter metabolism genes were studied in patients with prostate cancer (PC) characterized by either reduced or extended serum prostate-specific antigen doubling time corresponding to unfavorable...
COLUMBIA UNIVERSITY IRVING MEDICAL CENTER Adults with schizophrenia have an elevated risk of dying from suicide. Yet there’s only limited understanding of when and why people with schizophrenia die of suicide –in part because research studies have looked at relatively small groups of patients. Now a new study from Columbia that looked at a large...
by Will Doss, Northwestern University Neurons in the prefrontal cortex of mice modeling cognitive impairment in schizophrenia (scPCP model, right panel) show increased expression of NKCC1 transcript (dark dots) compared to control animals (left panel). Credit: Northwestern University Alterations in the balance of two chloride ion transporters may be responsible for cognitive deficits in schizophrenia, according...
