September 10, 2024 by VIB (the Flanders Institute for Biotechnology) Credit: Cell Reports (2024). DOI: 10.1016/j.celrep.2024.114719Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is the most common degenerative motor neuron disease in adults. It is characterized by a selective loss of motor neurons, resulting in progressive muscle weakness and paralysis, as well as...
by Academia Sinica Schematic representation of mechanisms involved in poly-GR/-PR-induced neuronal degradation and the potential therapeutic action of the sulfated disaccharide SOS. Credit: Academia SinicaAmyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases that commonly occur in middle-aged people. FTD is second only to Alzheimer’s disease in terms of dementia prevalence. Both ALS...
by Ohio State University Medical Center Regular exercise helps Paula Cole manage her multiple sclerosis symptoms. For years she felt helpless to fight her disease, but after connecting with a neurologist at The Ohio State University Wexner Medical Center, she is empowered to live well with the disease, and advocate for the increasing number of...
by The Mount Sinai HospitalImages of diseased spinal cords showing smaller demyelinated lesions when interleukin-3 is targeted. Credit: Mount Sinai Health System Cross-talk between brain cells and peripheral immune cells can modulate the progression of multiple sclerosis (MS), Mount Sinai researchers have discovered. Their findings reveal a previously unknown way in which the brain and immune...
by American Chemical Society Credit: CC0 Public Domain Drugs called interferon betas are common treatments for multiple sclerosis (MS), reducing relapses and slowing motor function decline. Interferon beta, a protein known to contain a zinc binding pocket, is thought to reduce proinflammatory molecules and even increase production of anti-inflammatory species in MS patients. But researchers now...
by Karolinska Institutet The disease multiple sclerosis (MS) attacks the central nervous system and, with time, can give rise to muscle tremors and loss of balance. Researchers at Karolinska Institutet have now identified a gene, Gsta4, that protects a certain kind of cell in the brain from being destroyed. It is hoped that the results...
During the COVID-19 pandemic, patients with multiple sclerosis (MS) and their clinicians have had questions and concerns about whether immunotherapies for MS could influence risk for infection or lead to an unfavorable outcome. In the Journal of Neurology, Rohit Bakshi, MD, a senior neurologist at Brigham and Women’s Hospital, and international co-authors present the cases...
by Greta Friar, Whitehead Institute for Biomedical Research Multiple sclerosis (MS) is a debilitating disease in which the body’s own immune system attacks itself and can, over time, permanently destroy the protective sheaths, or myelin, around nerve fibers in the brain. Myelin insulates nerve cells and facilitates the transmission of messages along them. When the...
(HealthDay)—Greater genetic predisposition for multiple sclerosis (MS) is associated with altered brain white matter development at an early age, according to a study published online March 12 in the Annals of Neurology. C. Louk de Mol, from the Erasmus University Medical Center Rotterdam in the Netherlands, and colleagues evaluated the association between MS polygenic risk...
