Tag: <span>senescence</span>

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2-bromopalmitate reduces senescence in human cells: Role of palmitoylation
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2-bromopalmitate reduces senescence in human cells: Role of palmitoylation

News Release 10-Sep-2024 “For the first time, the present study revealed a critical role for protein palmitoylation in the development of a DNA damage-induced senescence phenotype.” Peer-Reviewed PublicationImpact Journals LLC image: Figure 4. The influence of 2-BP treatment on the levels of senescence markers. The levels of p-p53 (A), HMGB1 (B), and lamin B1 (C)...

In Down syndrome cells, genome-wide disruptions mimic a senescence-like state
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In Down syndrome cells, genome-wide disruptions mimic a senescence-like state

by Massachusetts Institute of Technology Neural progenitor cells with the typical number of chromosomes show significant outward migration in culture (top). The culture in the bottom left shows untreated trisomy 21 cells. On the bottom right are cells treated with anti-senescence drugs, which restored migration. Credit: Alana Down Syndrome Center at MIT In Down syndrome,...