by Lori Solomon The U.S. Food and Drug Administration has approved an additional indication for AstraZeneca’s Fasenra (benralizumab) as an add-on maintenance treatment for patients aged 6 to 11 years with severe asthma and an eosinophilic phenotype. This indication was supported by evidence from the Phase III TATE trial, as well as data from additional...
by La Jolla Institute for Immunology Credit: Pixabay/CC0 Public Domain Asthma is more dangerous than many people realize. An estimated 10 Americans die everyday from asthma, and the disease leads to around 439,000 hospitalizations and 1.3 million emergency room trips each year. “Asthma is one of the most important allergic diseases to study,” says Professor Toshiaki...
Research from the Division of Pulmonary and Critical Care Medicine was featured prominently at the recent conference of the American Thoracic Society, the leading medical society focused on global respiratory health. Here are a few highlights: New treatment for severe asthma A greater proportion of patients with severe, uncontrolled asthma had more significant clinical responses to a...
by Kerry Noble, Imperial College London Adjusted HRs of COVID-19 hospitalization in children for different asthma status compared with children with no asthma. HRs of death COVID-19 hospitalization compared with people with no asthma, obtained from Cox regression models. Sociodemographic factors include, region, ethnicity, quintile of the Index of Multiple Deprivation. OCS, oral corticosteroids. Credit: Thorax (2022)....
Inhalers, pills or injections help most people control their asthma, but some with severe disease opt for cutting-edge surgery that “remodels” their airways to improve their breathing. Bronchial thermoplasty shrinks smooth muscle in the lungs, which prevents them from tightening up and causing an attack. The U.S. Food and Drug Administration approved the treatment for adults with severe asthma in...
TRINITY COLLEGE DUBLIN Scientists working in the School of Biochemistry and Immunology at the Trinity Biomedical Sciences Institute (TBSI) have uncovered a new approach for treating severe asthma. They have high hopes their discovery may pave the way for effective new treatments, especially in children. Ireland has one of the highest rates of asthma in...
Mark S. Lesney, PhD December 20, 2021 The US Food and Drug Administration (FDA) has approved tezepelumab-ekko (Tezspire) as a first in class treatment for severe asthma in adults and pediatric patients aged 12 years and older. It is not recommended for the relief of acute bronchospasm or status asthmaticus. Tezepelumab-ekko is a human monoclonal antibody that acts as...
by National Jewish Health Credit: DOI: 10.1056/NEJMoa2024257 A new monoclonal antibody therapy shows promise in offering an alternative treatment for patients suffering from moderate-to-severe asthma. Research led by Michael E. Wechsler, MD, MMSc, director of the National Jewish Health Cohen Family Asthma Institute, found that itepekimab was safe and effective in a phase 2 trial...
by University of Pittsburgh Credit: CC0 Public Domain Wheezing, coughing that doesn’t stop, a pale and sweaty face: clinically, severe asthma attacks look very similar from patient to patient. But biologically, not all severe asthma is the same—and a team of scientists has, for the first time, identified the key difference in people, a finding that has...
