Written by Ross Phan, PharmD, BCACP, BCGP, BCPS | Reviewed by Christina Aungst, PharmD Updated on April 26, 2022 Key takeaways: While it’s normal to experience sleeping difficulties every now and then, some people have chronic (long-term) insomnia that doesn’t go away. There are a number of medications, including zolpidem (Ambien), that can help relieve...
Written by Sonia Amin Thomas, PharmD, BCOP | Reviewed by Joshua Murdock, PharmD Published on June 13, 2022 Key takeaways: Advil (ibuprofen) is an affordable over-the-counter (OTC) pain reliever and fever reducer available in many different formulations. Motrin is another well-known brand name for ibuprofen. Advil has a risk of long-term side effects, such as...
UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER HOUSTON ― Researchers at The University of Texas MD Anderson Cancer Center have identified a novel strategy to reduce immune-related adverse events from immunotherapy treatment by targeting the cytokine interleukin-6 (IL-6). The study, published today in Cancer Cell, establishes a proof of concept for combining immune checkpoint blockade with cytokine blockers to selectively...
Pauline Anderson March 31, 2022 An investigational drug that blocks the dopamine-1 (D1) receptor reduces tics and is safe and well tolerated in children with Tourette syndrome (TS), a new study shows. Importantly, unlike current medications for the disorder, ecocipam does not lead to weight gain, anxiety, depression, or tardive dyskinesia compared to placebo ―...
by Perelman School of Medicine at the University of Pennsylvania Credit: Unsplash/CC0 Public Domain By uncovering the subtle difference between two varieties of a protein, researchers from the Perelman School of Medicine at the University of Pennsylvania may have discovered how to eliminate the risk of weight gain from a certain type of diabetes medications....
by Lancet Credit: Pixabay/CC0 Public Domain A review of adverse events following vaccination against COVID-19 with mRNA vaccines in the U.S. confirms that most side effects were mild and decreased substantially after one day. The new study, published in The Lancet Infectious Diseases journal, suggests that for more than 298 million vaccine doses administered between December 2020...
by Weill Cornell Medical College Illustration of the complex structure of S1P1, siponimod, and the Gi protein. The structure gives insights into how the drug activates the receptor. Credit: Dr. Xin-Yun Huang Investigators from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center have discovered how a drug for multiple sclerosis interacts with its targets, a finding that may...
by King’s College London Antiarrhythmic and ECG effects of OCT2013 versus lidocaine in rat Langendorff hearts. (a,e) Incidence of ventricular fibrillation (VF), (b,f) heart rate, (c,g) PR and (d,h) QT90 intervals during 30 min of regional ischaemia in hearts perfused with Krebs, OCT2013 or lidocaine. (a–d) Perfusion with test solution started 10 min before coronary ligation (onset of...
New research led by University of Manchester and NIHR Manchester Biomedical Research Centre (BRC) scientists has profiled the side effects of methotrexate – a common drug used to treat arthritis and other autoimmune diseases. The authors hope their findings – published in journal Rheumatology – will ease the concerns of patients before commencing treatment, who often lack...
JANUARY 8, 2022 by Georgia Institute of Technology Rendering of brain/neurons firing (NIH). Credit: NIH Severe and persistent disability often undermines the life-saving benefits of cancer treatment. Pain and fatigue—together with sensory, motor, and cognitive disorders—are chief among the constellation of side effects that occur with the platinum-based agents used widely in chemotherapy treatments worldwide. A...
