by Ludwig Maximilian University of Munich Pathway synopsis (I.) Sterile inflammation triggers the activation of a subset of cDCs, which respond by releasing CCL17. (II.) In turn, CCL17 binds to CCR8 on cDCs (autocrine) and on CD4+ T cells (paracrine) to stimulate an upregulation of CCL3 expression and release. (III.) Subsequently, CCL3 interacts with CCR1 on...
by University of Tsukuba Credit: Ukki Studio/Shutterstock A good night’s sleep can work wonders for both mind and body. But what is it that determines how much we need to sleep, and what can cause us to sleep more deeply? In a new study, researchers from the University of Tsukuba have now provided some answers,...
by Medizinische Hochschule Hannover Professor Dr. Ingmar Mederacke. Credit: Medizinische Hochschule Hannover At least 5 million people in Germany suffer from liver disease. Fibrosis, the pathological proliferation of connective tissue, plays an important role in many complications of chronic liver problems. Activated hepatic stellate cells (HSCs) are massively involved in this tissue remodeling. An international...
