September 24, 2024 by Lori Solomon Long-term use of skeletal muscle relaxants (SMRs) for chronic pain is only effective for certain conditions, such as painful spasms, painful cramps, and neck pain, according to a review published online Sept. 19 in JAMA Network Open. Benjamin J. Oldfield, M.D., from the Yale School of Medicine in New...
Tag: <span>skeletal muscle</span>
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Chronic inflammation and inactivity may affect age-related changes in gene and protein expression in skeletal muscle
by Wiley Credit: CC0 Public DomainNew research indicates that some age-related changes in gene and protein expression in the skeletal muscles of older individuals may be affected more by physical inactivity and chronic inflammation than primary aging, or intrinsic maturational processes. Physical inactivity and chronic inflammation are the most important drivers of secondary aging, or changes...
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Scientists reveal the mechanism of skeletal muscle stem cell activation in muscle regeneration
by Hong Kong University of Science and Technology Fig. 1: Discordant proteomic and transcriptomic signatures reveal a potential translational control mechanism during the SC quiescence-to-activation transition. a Schematic illustration of the workflow for the proteomic analysis of FACS-isolated SCs. The SCs were sorted from Pax7-nGFP mice. QSCs were sorted from 0.5% PFA-perfused mice. fiSCs were...
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Study shows protein that reverses aging of skeletal muscle
by Cory Nealon, University at Buffalo The illustration shows a senescent muscle cell (left), including the numerous factors that led to its declining ability to divide and grow. It also shows the same type of cell after the overexpression of NANOG, which reversed many of the factors. Credit: University at Buffalo A University at Buffalo-led research team has...
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Digging deep for differences in Duchenne muscular dystrophy
by UT Southwestern Medical Center Histopathology of gastrocnemius muscle from patient who died of pseudohypertrophic muscular dystrophy, Duchenne type. Cross section of muscle shows extensive replacement of muscle fibers by adipose cells. Credit: Public Domain A UT Southwestern research team has cataloged gene activity in the skeletal muscle of mice, comparing healthy animals to those carrying a genetic...
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Skeletal muscle development and regeneration mechanisms vary by gender
KUMAMOTO UNIVERSITY IMAGE: ERΒ CONTROLS MUSCLE GROWTH IN YOUNG FEMALE MICE ERΒ IS ESSENTIAL FOR MUSCLE REGENERATION IN FEMALE MICE INACTIVATION OF ERΒ CAUSES AN INCREASE IN APOPTOSIS ERΒ IS REQUIRED FOR SATELLITE CELL POPULATION EXPANSION Researchers at Kumamoto University, Japan generated mice lacking the estrogen receptor beta (ERβ) gene, both fiber-specific and muscle stem cell-specific, which...
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Consumption of a blueberry enriched diet by women for six weeks alters determinants of human muscle progenitor cell function
A NEW STUDY INVESTIGATED HOW SERUM FROM SUBJECTS CONSUMING A DIET ENRICHED WITH BLUEBERRIES WOULD AFFECT THE CELLS RESPONSIBLE FOR MUSCLE GROWTH AND REPAIR.view more CREDIT: U.S. HIGHBUSH BLUEBERRY COUNCIL FOLSOM, Calif. – August 5, 2020 – A new research study, published in the Journal of Nutrition, investigated how serum from subjects consuming a diet...
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Muscles support a strong immune system
GERMAN CANCER RESEARCH CENTER (DEUTSCHES KREBSFORSCHUNGSZENTRUM, DKFZ) PRINT E-MAIL In the fight against cancer or chronic infections, the immune system must be active over long periods of time. However, in the long run, the immune defence system often becomes exhausted. Scientists at the German Cancer Research Center (DKFZ) have now found initial evidence in mice...
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Older men with sarcopenia are more likely to develop diabetes over time
Older men with sarcopenia are more likely to develop diabetes over time New findings point to age-related muscle loss as a contributing factor to diabetes in the elderly THE ENDOCRINE SOCIETY PRINT E-MAIL WASHINGTON–Older men who have lower lean body mass as they age are more prone to developing diabetes, while similar findings were not...
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New UCI-led study defines best time to exercise to get the most rejuvenating results
UNIVERSITY OF CALIFORNIA – IRVINE A new study led by researchers from the University of California, Irvine finds exercising in the morning, rather than at night, may yield better results. This study, published today in Cell Metabolism, points to daily timing as a critical variable for metabolic benefits from exercise and implications in chronobiology-based exercise therapy for patients with metabolic disorders. “Using mice, we compared the...