Tag: <span>Small-molecule drug</span>

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Small molecule drug reverses ADAR1-induced cancer stem cell cloning capacity
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Small molecule drug reverses ADAR1-induced cancer stem cell cloning capacity

by University of California – San Diego A colorized scanning electron micrograph depicts human red blood cells. Credit: UC San Diego Health Sciences Researchers at University of California San Diego School of Medicine, Sanford Stem Cell Institute and Moores Cancer Center report that a late-stage, pre-clinical small molecule inhibitor, called rebecsinib, reverses malignant hyper-editing by an...

Small-molecule drug reverses neural effects of concussion
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Small-molecule drug reverses neural effects of concussion

by University of California, San Francisco Credit: Unsplash/CC0 Public Domain A small molecule called ISRIB that was identified at UC San Francisco can reverse the neuronal and cognitive effects of concussion in mice weeks after an injury occurred, new research has found. ISRIB blocks the integrated stress response (ISR), a quality control process for protein...