by Manchester Metropolitan University Elevated flow, cigarette smoke extract, and TNFα can trigger endothelial detachment, replicating features of plaque erosion in patients. Nrf2 activation or overexpression of OSGIN1&2 induces detachment of human coronary artery endothelial cells, likely through dysregulation of chaperone-mediated autophagy, that can be rescued by inhibition of HSP70 and 5′ AMP-activated protein kinase...
