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CAR T cells suppress GI solid tumor cells, without toxicity to healthy tissue, in preclinical research
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CAR T cells suppress GI solid tumor cells, without toxicity to healthy tissue, in preclinical research

by University of Pennsylvania CDH17 CARTs attack tumor but spare normal tissue. Credit: Penn Medicine Chimeric antigen receptor (CAR) T cells can be remarkably effective in treating leukemias and lymphomas, but there are no successful immunotherapies for neuroendocrine tumors (NETs) and gastrointestinal cancers (GICs) yet. Researchers at Penn Medicine have discovered that CAR-T cells directed to a...

Oncotarget: Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells
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Oncotarget: Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells

IMPACT JOURNALS LLC IMAGE: Relacorilant improves the efficacy and promotes the apoptotic activity of cytotoxic therapy in xenograft models under physiological cortisol conditions. (A) In the MIA PaCa-2 model, the efficacy of the combination of paclitaxel + relacorilant was significantly better than paclitaxel alone (non-parametric T-test P < 0.0001). (B) In the MIA PaCa-2 model,...