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Finding the source of debilitating, body-wide muscular pain and weakness
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Finding the source of debilitating, body-wide muscular pain and weakness

by Tokyo Medical and Dental University PD-1+CD8+ T cells were activated rather than exhausted. PD-1+CD8+ T cells infiltrated muscle tissues. Affected muscles reacted to IFNγ, which could be produced from effector T cells, as a danger signal and then expressed PD-L1. Muscles countered PD-1+CD8+ T cell attacks through the enhancement of PD-L1 expression. Credit: Department of...