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Sox9 protein enables molecular ‘time travel’ that can lead to colorectal cancer
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Sox9 protein enables molecular ‘time travel’ that can lead to colorectal cancer

by Dana-Farber Cancer Institute Elevated expression of Sox9 and reduced expression of differentiation genes in murine models of intestinal neoplasia. A. Diagram showing breeding scheme to achieve Lgr5-Apcf/f-tdT mice for conditional Apc inactivation. B. Representative images showing gross anatomy of duodenal intestines from indicated mice. C. Heat map of intestinal stem cell (red) and differentiation...