by Nancy Fliesler, Children’s Hospital Boston Researchers have now mapped all the neurons that project from the brain to the spinal cord and characterized them at the molecular level — adding to a larger cell-by-cell “atlas” of the mouse brain. Credit: Sebastian Stankiewicz, Boston Children’s HospitalOnly a fraction of people who sustain a spinal cord injury...
by Emmanuel Barraud, Ecole Polytechnique Federale de Lausanne The development of flexible electrodes has led to the first clinical applications in paraplegic patients and then in a Parkinson’s patient. Credit: EPFL – CC-BY-SA 4.0Grégoire Courtine, Jocelyne Bloch and their research team have been breaking new ground in the treatment of neurological disorders for over a decade....
Peer-Reviewed Publication OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER AN SCHWAB, MD, PHD, IS THE WILLIAM E. HUNT & CHARLOTTE M. CURTIS CHAIR AND A PROFESSOR OF NEUROLOGY AND NEUROSCIENCES AT THE Ohio State College of Medicine. SCHWAB IS ALSO MEDICAL DIRECTOR OF THE Belford Center for Spinal Cord Injury AND A SCHOLAR OF THE CHRONIC...
by Ohio State University Medical Center Credit: Pixabay/CC0 Public Domain Acute spinal cord injury (SCI) patients lose body weight and muscle mass, despite being on a high-calorie diet while in the intensive care unit. Their muscle wasting is substantial and extends beyond what can explained by inactivity or denervation (loss of nerve supply) alone. Research led...
by Laurie Fickman, University of Houston Riluzole trough and peak concentrations from Phase I and Phase II/III trials presented in waterfall plots. Credit: Journal of Neurotrauma (2023). DOI: 10.1089/neu.2022.0499 A small clinical trial with a pharmacokinetic sub-study, led by a pharmacologist at the University of Houston, has demonstrated the promising effectiveness of the drug Riluzole for...
by Olivia Dimmer, Northwestern University Neurons treated with the N1-PA nanofiber exhibited more neurite outgrowth than control neurons. Credit: Stupp LaboratoryNorthwestern Medicine scientists have developed a molecular “scaffold” capable of enhancing electrical activity and growth in neurons, which may prove useful in treating spinal cord injuries, according to recent results published in ACS Nano. According to...
by City University of Hong Kong The transplanted SOX9-suppressed neural stem cells (bottom) at injured site generated robust axons extending into the host spinal cord after 3 months post-graft. Credit: Advanced Science (2023). DOI: 10.1002/advs.202205804 A research team co-led by City University of Hong Kong (CityU) and The University of Hong Kong (HKU) has recently made a significant...
by King’s College London KCL-286 transcriptional neuronal signaling. KCL-286 binds to a retinoic acid receptor (RAR)β2/retinoid x receptor (RXR) heterodimer located at a retinoic acid response element (RARE). This results in activation of transcriptional pathways required for axonal regeneration. Credit: British Journal of Clinical Pharmacology (2023). DOI: 10.1111/bcp.15854 New orally available drug for spinal cord injury found to...
by The Ohio State University B Cells Extravasate, Convert Into Plasma Cells, and Synthesize Antibodies in Subacute Spinal Cord Injury (SCI) Lesions After Human SCI. B cells leave the vessel lumen (extravasate) and populate the perivascular space (2 weeks after SCI). These findings are corroborated by the detection of 2 different B cell antigens, CD20...
UNIVERSITY OF CALIFORNIA – SAN DIEGO IMAGE: MARK TUSZYNSKI, MD, PHD, IS A PROFESSOR OF NEUROSCIENCES AND DIRECTOR OF THE TRANSLATIONAL NEUROSCIENCE INSTITUTE AT UC SAN DIEGO SCHOOL OF MEDICINE. CREDIT: UC SAN DIEGO HEALTH SCIENCES In recent years, researchers have made measurable progress, using animal models, to promote tissue regeneration in spinal cord injuries...
