by King’s College London KCL-286 transcriptional neuronal signaling. KCL-286 binds to a retinoic acid receptor (RAR)β2/retinoid x receptor (RXR) heterodimer located at a retinoic acid response element (RARE). This results in activation of transcriptional pathways required for axonal regeneration. Credit: British Journal of Clinical Pharmacology (2023). DOI: 10.1111/bcp.15854 New orally available drug for spinal cord injury found to...
by The Ohio State University B Cells Extravasate, Convert Into Plasma Cells, and Synthesize Antibodies in Subacute Spinal Cord Injury (SCI) Lesions After Human SCI. B cells leave the vessel lumen (extravasate) and populate the perivascular space (2 weeks after SCI). These findings are corroborated by the detection of 2 different B cell antigens, CD20...
UNIVERSITY OF CALIFORNIA – SAN DIEGO IMAGE: MARK TUSZYNSKI, MD, PHD, IS A PROFESSOR OF NEUROSCIENCES AND DIRECTOR OF THE TRANSLATIONAL NEUROSCIENCE INSTITUTE AT UC SAN DIEGO SCHOOL OF MEDICINE. CREDIT: UC SAN DIEGO HEALTH SCIENCES In recent years, researchers have made measurable progress, using animal models, to promote tissue regeneration in spinal cord injuries...
INDIANA UNIVERSITY SCHOOL OF MEDICINE INDIANAPOLIS—Spinal cord and brain injury researchers at Indiana University School of Medicine are studying new alternatives to promote functional recovery after a spinal cord injury. In a paper recently published in JCI Insight, the team of researchers used models in the lab to investigate a unilateral spinal cord injury similar to Brown-Sequard...
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN IMAGE: A SPINE GRAPHIC CREDIT: MICHIGAN MEDICINE Adults living with spinal cord injuries have a near-80% increased risk of developing psychological conditions, such as depression and anxiety, compared to people without the traumatic injury, a new study shows. But chronic pain may have an equally large, negative effect on...
by Zhang Nannan, Chinese Academy of Sciences Schematic diagram of the dual-functional immunoregulatory hydrogel for regulating the inflammatory microenvironment after spinal cord injury. Credit: IGDB Researchers led by Prof. Dai Jianwu from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences developed a multifunctional scaffold to effectively regulate the immune microenvironment...
OSAKA UNIVERSITY Mitsubishi Tanabe Pharma Corporation (MTPC, Head Office: Chuo-ku, Osaka; President & Representative Director, CEO: Hiroaki Ueno) and Professor Toshihide Yamashita at the Department of Molecular Neuroscience and Department of Neuro-Medical Science, Osaka University Graduate School of Medicine, announced today that MTPC’s research and development subsidiary in the US, Mitsubishi Tanabe Pharma Development America, Inc. (MTDA)...
Mammals have a poor ability to recover after a spinal cord injury which can result in paralysis. The main reason for this is the formation of a complex scar associated with chronic inflammation that produces a cellular microenvironment that blocks tissue repair. Now, a research team led by Leonor Saude, group leader at Instituto de...
by Medical College of Georgia at Augusta University Dr. Hedong Li Credit: Chris Thelen Cells called astrocytes normally support our neurons, and now scientists are working to reprogram the star-shaped cells into neurons that help reconnect the brain and body after a spinal cord injury. “We are at the stage of optimization. We know this reprogramming...
INDIANA UNIVERSITY SCHOOL OF MEDICINE IMAGE: FROM LEFT, WEI WU, PHD, AND XIAO-MING XU, PHD CREDIT: IU SCHOOL OF MEDICINE Researchers at Indiana University School of Medicine have successfully reprogrammed a glial cell type in the central nervous system into new neurons to promote recovery after spinal cord injury–revealing an untapped potential to leverage the cell...
