by University of California, Los Angeles Microscope images showing brain tissue that has been damaged by white matter stroke (left) and then repaired by the new glial cell therapy (right). Myelin (seen in red), is a substance that protects the connections between neurons and is lost due to white matter stroke. As seen at right, the...
ALPHAMED PRESS IMAGE: EXAMPLES OF COMPLETE CLOSURE (100%). CREDIT: ALPHAMED PRESS Durham, NC – According to the results of a phase 1 clinical trial just published in STEM CELLS Translational Medicine, a new stem cell therapy shows promise of making diabetes-related amputations a thing of the past. The trial involved injecting diabetes patients suffering from non-healing...
BY DAVID MELAMED, PHD Seneca Biopharma announced that work is underway to advance NSI-566, its leading stem cell treatment candidate, into a Phase 3 study in people with amyotrophic lateral sclerosis (ALS). The decision followed a meeting with the US Food and Drug Administration (FDA), and is supported by data collected from a Phase 1...
If approved, the treatment could restore vision. A Japanese committee has provisionally approved the use of reprogrammed stemcells to treat diseased or damaged corneas. Researchers are now waiting for final approval from the health ministry to test the treatment in people with corneal blindness, which affects millions of people around the world. The cornea, a transparent layer...
A new treatment which reboots the immune system using stem cell transplantation could relieve MS symptoms Multiple sclerosis (MS), a disease roughly 5,000 people are diagnosed with in the UK every year, is unpredictable and notoriously difficult to treat. That might all be about to change thanks to a breakthrough stem cell study that...
Young women with premature ovarian insufficiency (POI) may be able to use their own bone marrow stem cells to rejuvenate their ovaries and avoid the effects of premature menopause, new research suggests. The preliminary results from the ongoing ROSE clinical trial will be presented Tuesday at ENDO 2018, the 100th annual meeting of the Endocrine Society, in...
415 million people worldwide have been diagnosed with diabetes. And the number continues to rise. Common to all diabetes patients is that they lack the ability to produce sufficient amounts of insulin, which regulates the blood sugar in the body. This can lead to a number of complications and in many cases be potentially fatal....
Highlights A GMP-compatible iPSC source has been generated from peripheral blood cells An industry-friendly protocol has been developed to produce NK cells from iPSCs These iPSC-derived NK cells are high-purity, functional, and KIR negative These iPSC-derived NK cells recognize and kill a wide variety of cancer cells Summary Current donor cell-dependent strategies can only produce...
Highlights PSEN1 mutant AD astrocytes manifest hallmarks of AD pathology Altered mitochondrial metabolism in AD astrocytes increases oxidative stress AD astrocytes reduce the calcium signaling activity of healthy neurons Astrocytes are important in the pathogenesis of AD Summary Alzheimer’s disease (AD) is a common neurodegenerative disorder and the leading cause of cognitive impairment. Due to insufficient...
Increasing levels of a certain protein in blood stem cells so that the immune system stops attacking insulin cells in the pancreas could be a way to halt type 1 diabetes, according to a new study reported in Science Translational Medicine. Scientists may have devised a way to reverse type 1 diabetes. Researchers led by those...
