People who have received transplants for blood cancer, some more than 40 years ago, do not have high rates of potentially cancer-causing mutations Haematopoietic stem cells from donors have been used to treat hundreds of thousands of people with blood cancer and other blood disorders.Credit: SPL Ever since the first blood-forming stem cells were successfully...
Tag: <span>stem cell transplantation</span>
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Initial patient dosed in Phase 2a clinical trial evaluating first-in-class human milk-based therapy in patients undergoing stem cell transplantation for blood cancers
Seeking strategic partners for continued clinical development of PBCLN-010 with PBCLN-014, a lead investigational therapy comprising human milk sugars and gut bacteria found in nursing infants Business Announcement PROLACTA BIOSCIENCE DUARTE, Calif., Nov. 10, 2023 – In a breakthrough for human milk science, researchers at City of Hope, Los Angeles, have dosed the first patient...
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Endogenous molecule protects from life-threatening complications after stem-cell transplantation
by Rimma Gerenstein, Albert-Ludwigs-Universität Freiburg im Breisgau Orally administered hBD-2 is detectable in organs of hBD-2-treated aGVHD mice. The allo-HCT major mismatch model C57BL/6→BALB/c was used. Mice were treated once daily with hBD-2 (n=5) or PBS (n=3) from day 0 until day 7. hBD-2 concentrations in organs were quantified by LC-MS/MS. Credit: Science Translational Medicine (2022). DOI:...
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BU study: Stem cell transplantation for AL amyloidosis leads to long-term survival and possible cure in selected patients
BOSTON UNIVERSITY SCHOOL OF MEDICINE (Boston)—AL amyloidosis is a life-threatening disease related to bone marrow cancer, multiple myeloma. It is caused when a person’s antibody-producing white blood cells (i.e. plasma cells) do not function properly and generate abnormal protein which misfolds to form amyloid fibrils and deposits made of components of antibodies called light chains,...
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Stem Cell Transplantation a Potential Game Changer for MS?
Nancy A. Melville March 03, 2022 WEST PALM BEACH, Florida — Stem cell transplantation is tied to complete elimination of relapse in patients with aggressive multiple sclerosis (MS), new long-term data show. In a retrospective study, investigators found patients with aggressive MS treated with autologous hematopoietic stem cell transplant (aHSCT) experienced complete elimination of relapse, with no...
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Stem Cell Transplantation to Treat Chronic Inflammation and Frailty
Today’s open access commentary is a good companion piece to a recent paper covering the use of mesenchymal stem cell therapies to suppress age-related chronic inflammation. These first-generation stem cell therapies have proven to be unreliable when it comes to the original goal of regeneration of organ function, but they do reliably reduce excessive inflammation for some months. Transplanted stem...
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Undesirable rejection mechanism identified in stem cell transplantation
by Medical University of Vienna In the treatment of leukemia, stem cell transplantation subsequent to chemotherapy and radiation can often engender severe adverse inflammatory reactions—especially in the skin or in the gut, since these so-called barrier organs are more frequently affected. Up until now, the reason for this was unclear. A MedUni Vienna team led by...
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Transplanted brown-fat-like cells hold promise for obesity and diabetes
by Joslin Diabetes Center Microscopic images of the various types of fat tissues developed in mice after transplantation. Top panels show the fat tissue’s general morphology, and the bottom panels are the tissue sections stained with hUCP1 (red color), which is unique for brown fat cells. These images show that while the HUMBLE fat cells...
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Critical window for re-infection with HIV after stem cell transplantation
Some people with HIV need to undergo an allogeneic stem cell transplantation in order to treat different types of blood cancer. Most of the patient’s immune cells are eliminated during these transplantations. Stem cells from a healthy donor are then used to replace the patient’s damaged bone marrow and restore their immune system. “In the...
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New multiple sclerosis treatment trial compares stem cell transplantation to best available drugs
A clinical has begun trial testing an experimental stem cell treatment against the best available biologic therapies for severe forms of relapsing multiple sclerosis (MS). The trial, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, will compare the safety, efficacy and cost-effectiveness of the two...
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