by The Mount Sinai Hospital Micrograph showing inflammation of the large bowel in a case of inflammatory bowel disease. Colonic biopsy. Credit: Wikipedia/CC BY-SA 3.0 Mount Sinai researchers have published one of the first studies to demonstrate the importance of reactive oxygen species in maintaining stem cell function and preventing inflammation during wound repair, which could...
by Cedars-Sinai Medical Center Credit: CC0 Public Domain Cedars-Sinai investigators have developed an investigational therapy using support cells and a protective protein that can be delivered past the blood-brain barrier. This combined stem cell and gene therapy can potentially protect diseased motor neurons in the spinal cord of patients with amyotrophic lateral sclerosis, a fatal...
by Institute of Science and Technology Austria Stem cells divide at the bottom of the intestinal crypts and the resulting cells are pushed upwards to the top pf the villi where they are discarded. Credit: © Shutterstock A special layer of cells that coats the insides of the small and large intestines takes in nutrients and...
by Sarah Nightingale, University of Southern California Frank Petrigliano, MD, (left) and Denis Evseenko, MD, PhD. Credit: Ricardo Carrasco III A novel off-the-shelf bio-implant containing embryonic stem cells has the potential to revolutionize the treatment of cartilage injuries More than a million Americans undergo knee and hip replacements each year. It’s a last resort treatment for...
by Julia Evangelou Strait, Washington University School of Medicine Studying mice, researchers at Washington University School of Medicine in St. Louis have developed a method of stem cell transplantation that does not require radiation or chemotherapy. Above, the right panel shows mouse bone marrow after the debilitating effects of radiation followed by an infusion of donor...
This open access paper reviews the relationship between DNA damage and inflammation in the specialized environments that support stem cell populations. Aging produces many changes that lead to reduced stem cell function. Changes in the niche, the supporting cells that help to ensure stem cells retain their function, are of increasing interest to the research community. The chronic inflammation of aging is also an area...
by Marla Paul, Northwestern University Strand of human hair at 200x magnification. Credit: Jan Homann/Wikipedia A newly discovered cause of balding in aging male mice could reveal a cause of hair loss in men and women as well, reports a study from Northwestern Medicine scientists. The findings provide new insight into how hair and tissues age....
By Gina Kolata By observing mouse hair follicles, scientists discovered an unexpected mechanism of aging. “If I didn’t see it with my own eyes I wouldn’t believe it,” one said. Researchers have found that hair loss from aging results from stem cells escaping hair follicles.Credit…Alamy Every person, every mouse, every dog, has one unmistakable sign of...
IMAGE: TWENTY-SIX PATIENTS WITH XIAP DEFICIENCY UNDERWENT HCT BY THE END OF MARCH 2020, AND 22 (84.6%) SURVIVED. IBD IMPROVED REMARKABLY AFTER HCT. GUT MICROBIOTA INDICATED DYSBIOSIS BEFORE HCT; HOWEVER, IT WAS IMPROVED TO RESEMBLE THAT OF THE HEALTHY FAMILY MEMBERS AFTER HCT. THIS STUDY REVEALED THAT HCT HAS A FAVORABLE OUTCOME FOR XIAP DEFICIENCY....
“What do you want to be when you grow up?” is a question it seems like every child gets asked. A few precocious ones might answer “a doctor” or “an astronaut,” but most will probably smile and shrug their shoulders. But well before a child could comprehend the question or the concept of choosing one’s...
