by Hokkaido University In mice large intestine, the goblet cells (blue) are significantly reduced in number after allogeneic bone marrow transplantation (right), comparing to a control syngeneic recipients (left). Allogeneic stem cell transplantation can cause a loss of protective goblet cells from the colon’s inner lining, which can be fatal. But boosting those cells beforehand...
by University of North Texas Health Science Center When news of the coronavirus emerged from Wuhan, China, Kunlin Jin, Ph.D., and a team of international researchers quickly joined forces to fight the mysterious disease. Dr. Jin relied on his more than 20 years of knowledge about stem cells to work with an international team driven...
By Michael Irving Stanford scientists may have found a way to essentially return older cells to a more youthful state. The adult cells are treated with a mix of proteins from early embryonic development, which removes many of the molecular signs of aging. The cells closely resembled younger ones, and in mouse tests, older animals...
Genomic profiles can be used to classify patients by risk of relapse after transplant DANA-FARBER CANCER INSTITUTE For older patients with acute myeloid leukemia (AML), the prospects for success of a stem cell transplant can often be predicted based on the particular set of genetic mutations within the tumor cells, investigators at Dana-Farber Cancer Institute...
ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE How do temporal variations in protein concentrations affect biology? It’s a question that biologists have only recently begun to address, and the findings are increasingly showing that random temporal changes in the amount of certain proteins play a direct and significant role on biological processes. In a new study published...
by Mary Ann Liebert, Inc Cells equipped with super paramagnetic iron oxide nanoparticles (SPIOs) can be directed to a specific location by an external magnetic field, which is beneficial for tissue repair. Researchers have now taken the important step of evaluating the safety and efficacy of magnetically labeled mesenchymal stem cells (MSCs) for use in repairing...
Luxembourg, 28 February 2019 – Scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and from the German Cancer Research Center (DKFZ) have been able to rejuvenate stem cells in the brain of aging mice. The revitalised stem cells improve the regeneration of injured or diseased areas in the brain...
Cell replacement may play an increasing role in alleviating the motor symptoms of Parkinson’s disease (PD) in future. Writing in a special supplement to the Journal of Parkinson’s Disease, experts describe how newly developed stem cell technologies could be used to treat the disease and discuss the great promise, as well as the significant challenges,...
Is gene therapy the answer to sickle cell disease? An experimental treatment that promises to correct the condition at the genetic level has already shown great promise in a clinical trial. Researchers reported that a patient who has gone through gene therapy to cure sickle cell disease no longer experiences symptoms and has an increased...
Researchers at The Ottawa Hospital and the University of Ottawa have discovered a new way to treat the loss of muscle function caused by Duchenne muscular dystrophy in animal models of the disease. As reported in Cell Stem Cell, the team restored muscle stem cell function that is impaired in Duchenne muscular dystophy, resulting in...
