U-M cell biologists & engineers show how pluripotent stem cells self-organize into a structure similar to an early stage of human development ANN ARBOR, Mich. – The first few weeks after sperm meets egg still hold many mysteries. Among them: what causes the process to fail, leading to many cases of infertility. Despite the importance...
Tag: <span>Stem Cell</span>
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Advance furthers stem cells for use in drug discovery, cell therapy
Since highly versatile human stem cells were discovered at the University of Wisconsin-Madison nearly 20 years ago, their path to the market and clinic has been slowed by a range of complications. Both embryonic stem cells and induced pluripotent stem cells are valued for their ability to form any cell in the body. This week, a UW-Madison team reports...
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Stem-cell researchers solve mystery of relapse in acute myeloid leukemia
Leukemia researchers led by Dr. John Dick have traced the origins of relapse in acute myeloid leukemia (AML) to rare therapy-resistant leukemia stem cells that are already present at diagnosis and before chemotherapy begins. They have also identified two distinct stem-cell like populations from which relapse can arise in different patients in this aggressive cancer...
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Battle to stay alive: Young soldier and father with aggressive blood cancer issues urgent appeal for life-saving stem cell donors
Private Myles Brown, 27, has rare type of leukaemia which progresses fast It’s possibly spread to his brain and his only hope is a stem cell transplant Without it, he would have two years of chemo which could ravage his health Mr Brown, from Lincolnshire, wants to live for his 18-month-old daughter Lilian He has...
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Stem Cells May Be the Key to Staying Strong in Old Age
University of Rochester Medical Center researchers have discovered that loss of muscle stem cells is the main driving force behind muscle decline in old age in mice. Their finding challenges the current prevailing theory that age-related muscle decline is primarily caused by loss of motor neurons. Study authors hope to develop a drug or...
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A protein that stem cells require could be a target in killing breast cancer cells
Researchers have discovered that a chromatin-regulating protein called BPTF must be present for stem cells in the breast to perform their normal functions — maintaining a supply of stem cells and seeding the breast with specialized new …more For years, cancer experts have realized that cancerous cells behave in certain ways like stem cells, unspecialized...
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Cold virus, stem cells tested to destroy deadly brain cancer
Killer T cells surround a cancer cell. A first-of-a-kind neural stem cell therapy that works with a common cold virus to seek out and attack a lethal and aggressive brain cancer is being tested at Northwestern Medicine in a Phase I clinical trial for patients newly diagnosed with malignant glioma. The novel drug to...
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Is this the end of blood donation? Scientists close to unlimited supply from stem cells
Blood donors may no longer be needed in the future after scientists showed it was possible to create blood from stem cells. The 20 year project could pave the way for an unlimited number of blood and immune cells for transplants, simply by reprogramming a patient’s own skin cells. The research, reported in the journal...
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Stem cell innovation regrows rotator cuffs
A team of researchers from UConn Health has found a way to regenerate rotator cuff tendons after they’re torn, using a nano-textured fabric seeded with stem cells. Every time you throw a ball, swing a golf club, reach for a jar on a shelf, or cradle a baby, you can thank your rotator cuff....
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Protection for the gut barrier: New approach may prevent graft-versus-host disease
Stem cell transplants can save lives, for example in patients with leukemia. However, these treatments are not free of risks. One complication that may occur is graft-versus-host disease (GVHD), basically donor-derived immune cells attacking the recipient’s body. A team at the Technical University of Munich (TUM) has identified molecular mechanisms that may protect patients against...