Stem cell transplants can save lives, for example in patients with leukemia. However, these treatments are not free of risks. One complication that may occur is graft-versus-host disease (GVHD), basically donor-derived immune cells attacking the recipient’s body. A team at the Technical University of Munich (TUM) has identified molecular mechanisms that may protect patients against...
Tag: <span>Stem Cell</span>
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Graphene, electricity used to change stem cells for nerve regrowth
Iowa State University researchers, left to right, Metin Uz, Suprem Das, Surya Mallapragada and Jonathan Claussen are developing technologies to promote nerve regrowth. The monitor shows mesenchymal stem cells (the white) aligned along graphene circuits (the black). Researchers looking for ways to regenerate nerves can have a hard time obtaining key tools of their trade....
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Artificial thymus can produce cancer-fighting T cells from blood stem cells
T cells (red) that were produced using artificial thymic organoids developed by UCLA scientists. UCLA researchers have created a new system to produce human T cells, the white blood cells that fight against disease-causing intruders in the body. The system could be utilized to engineer T cells to find and attack cancer cells, which...
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Method identified to boost detection of highly cancerous stem cells
Cancer stem cells (CSCs) escape from 5-aminolevulinic acid (5-ALA)-based photodynamic detection (PDD) (upper panel). An iron chelator deferoxamine (DFO) enhances accumulation in CSCs of PpIX from 5-ALA, which will facilitate the elimination …more Japanese researchers identify process to improve fluorescence detection of cancer stem cells, which are primarily responsible for brain tumor progression and recurrence...
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The stem cell dynamics of wound healing
Researchers at the Université libre de Bruxelles, ULB define for the first time the changes in the stem cell dynamics that contribute to wound healing. One of the key questions in biology is to identify how tissues are repaired after trauma and understand how stem cells migrate, proliferate, and differentiate to repair tissue damage. In a study...
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Researchers engineer new thyroid cells
Researchers have discovered a new efficient way to generate thyroid cells, known as thyrocytes, using genetically modified embryonic stem cells. Researchers have discovered a new efficient way to generate thyroid cells, known as thyrocytes, using genetically modified embryonic stem cells. The findings, which appear in the journal Stem Cell Reports, are the first step to developing...
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Stem cells collected from fat may have use in anti-aging treatments
Adult stem cells collected directly from human fat are more stable than other cells — such as fibroblasts from the skin — and have the potential for use in anti-aging treatments, according to researchers from the Perelman School of Medicine at the University of Pennsylvania. They made the discovery after developing a new model to...
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Stem cell strategy for boosting testosterone levels tested in rodents
Male hypogonadism is a condition that diminishes testosterone levels in approximately 30% of older men, but currently available therapies can produce serious side effects. In a study published December 22 in Stem Cell Reports, researchers developed an alternative approach involving the direct conversion of adult skin cells into functional testosterone-producing cells. When transplanted into male rodents...
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New findings about stem cells in the brain of patients with epilepsy
Neural stem cells have been found in epileptic brain tissue — outside the regions of the brain where they normally reside. In a group of patients who underwent surgery for epilepsy, over half had stem cells where healthy individuals do not have them, according to a study from Sahlgrenska Academy. “We have confirmed what earlier...
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Lipid metabolism is potential ‘Achilles’ heel’ for cancer stem cells
WEST LAFAYETTE, Ind. — Researchers have discovered a metabolic signature critical for the functioning of “cancer stem cells” that initiate tumor formation. The team also showed how to interfere with this metabolic mechanism in ovarian cancer, inhibiting tumor growth. “The cancer stem cells are resistant to conventional therapies and are responsible for tumor relapse after...