September 25, 2024 by Johns Hopkins University School of Medicine Cell line variation in the emergence of neural fate from pluripotency (A) Spatial expression on day 6 in SR condition in SA01 and i04 lines.(B) Variation in NANOG and SOX21 expression across PSC lines. (i) Representative images. Scale bar, 100 μm. (ii) Expression levels in...
Tag: <span>Stem Cells</span>
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HiTIP-seq profiles epigenomic reprogramming of patient-derived diffuse midline glioma stem cells to epigenetic therapy
News Release 24-Sep-2024 Peer-Reviewed PublicationTsinghua University Press image: Diffuse midline glioma (DMG), H3K27-altered, is a lethal pediatric high-grade tumor, lacking effective treatment options, primarily depending on clinical trials. Epigenetic agent-based immunotherapy has shown promise, but the underlying mechanisms remain unclear. To address the scarcity of tumor samples, researchers utilize patient-derived tumor cells to explore DMG...
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Diabetes took over her life, until a stem cell therapy freed her
Scientists are making progress replacing the critical insulin-producing cells that are destroyed by the disease. By Carolyn Y. JohnsonAugust 26, 2024 at 5:00 a.m. EDT For years, Amanda Smith and her husband were jolted awake at night by a buzz-buzz-beep — an alarm warning that her blood sugar was too high or too low. She...
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New way to extend ‘shelf life’ of blood stem cells will improve gene therapy
SCIENCE & TECHNOLOGY NEWS Researchers have discovered a way to extend the shelf life of blood stem cells outside the body for gene therapy, providing patients with better options and improving their outcomes. Researchers have identified a drug already used for cancer patients, that, when applied to current gene therapy protocols can improve blood stem...
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Inflammation imprints lasting effects on intestinal stem cells, researchers discover
September 3, 2024 by Molly Chiu, Baylor College of Medicine Credit: Cell Stem Cell (2024). DOI: 10.1016/j.stem.2024.08.006Researchers at Baylor College of Medicine, the University of Michigan and collaborating institutions have discovered that inflammation in the gut leaves long-term marks on intestinal stem cells (ISCs) that reduce their ability to heal the intestine, even after inflammation...
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Blood stem cell research could transform bone marrow transplants
September 2, 2024 by Murdoch Children’s Research Institute Credit: Unsplash/CC0 Public Domain Melbourne researchers have made a world first breakthrough in creating blood stem cells that closely resemble those in the human body. And the discovery could soon lead to personalized treatments for children with leukemia and bone marrow failure disorders. The research, led by...
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Potential new approach to enhancing stem-cell transplants
August 8, 2024 by Albert Einstein College of Medicine Credit: Pixabay/CC0 Public Domain A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body’s different blood...
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Stem cell therapy advances: MSCs show potential in managing COVID-19 and influenza infections
Announcing a new article publication for BIO Integration journal. The emergence of infectious diseases, including viral zoonoses, has allowed intensive research into novel therapeutic approaches. Stem cell therapy, mostly using mesenchymal stem cells (MSCs), has garnered significant attention due to the immunomodulatory properties and tissue repair capabilities. MSCs have demonstrated promise in treating severe COVID-19...
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Sorting therapeutic stem cells by function improves healing after heart attack
SCIENCE & TECHNOLOGY NEWS Selecting specific cells to be used in an investigational therapy led to improved recovery of heart function in a new study employing a lab model for myocardial infarction, the medical term for heart attacks.A team led by researchers at the California NanoSystems Institute at UCLA and Columbia University developed a sorting...
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Study provides new insights into fighting leukemia by targeting its stem cells
JULY 24, 2024 by University of Geneva Credit: Unsplash/CC0 Public DomainAcute myeloid leukemia (AML) is the most common blood and bone marrow cancer in adults. Caused by an increase in immature cells that rapidly destroy and replace healthy blood cells (red and white blood cells and platelets), AML is lethal in half of those affected...