Sanford Health is launching its second adipose-derived stem cell clinical trial – this one to focus on non-healing leg wounds. The trial, which opened in September with expanded criteria, is a phase 1 trial to study the safety and efficacy of using adipose-derived stem cell therapy as a treatment for non-healing leg ulcers. It’s open to participants...
Tag: <span>Stem Cells</span>
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Team creates functional, stem-cell-derived small bowel segments
A decellularized loop of rat small bowel after repopulation, with stem-cell-derived human epithelial cells (green) lining the intestine and endothelial cells (red) lining the blood vessels. Using human induced pluripotent stem cells (iPSCs), a Massachusetts General Hospital research team has bioengineered functional small intestine segments that, when implanted into rats, were capable of deliver...
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Dentists Find Tooth Root Pulp Can Become an Alternative Source of Stem Cells
IN BRIEF A team of dentists and scientists from the University of Nevada, Las Vegas has found a rich new source of stem cells. Tooth root pulps, they discovered, were home to both pluripotent and multipotent cells. The team also developed a way to extract them without damaging the cells. WISDOM IN TEETH A collaboration...
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The protein TAZ sends ‘mixed signals’ to stem cells
IMAGE: THE PROTEIN TAZ (GREEN) IN THE CYTOPLASM (THE REGION OUTSIDE OF THE NUCLEI, BLUE) PROMOTES THE SELF-RENEWAL OF HUMAN EMBRYONIC STEM CELLS. Just as beauty exists in the eye of the beholder, a signal depends upon the interpretation of the receiver. According to new USC research published in Stem Cell Reports, a protein called TAZ...
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What are Stem Cells, Exactly? [Fact Sheet]
tem cells can multiply (self-renew) and differentiate into every cell within the human body, giving them enormous potential for use in regenerative medicine. In a developing embryo, stem cells can differentiate into all of the specialized embryonic tissues. In adult humans, stem and progenitor cells act as a repair system for the body, replenishing specialized...
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Upon prolonged irradiation, human stem cells’ defenses are activated
Researchers from several Russian institutes, including MIPT, have found out how prolonged exposure to ionizing radiation affects human stem cells. They discovered that it causes a cell cycle delay, which leads to faster repairs of radiation-induced DNA double-strand breaks, with fewer errors. It is unclear what the health implications are, particularly how this affects the...
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Scientists develop barcoding tool for stem cells
New genetic barcoding technology allows scientists to identify differences in origin between individual blood cells. New technology that tracks the origin of blood cells challenges scientific dogma A 7-year-project to develop a barcoding and tracking system for tissue stem cells has revealed previously unrecognized features of normal blood production: New data from Harvard Stem Cell...
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Cardiac stem cells from young hearts could rejuvenate old hearts, new study shows
Animal study reveals that cardiosphere-derived cells secrete tiny vesicles that could ‘turn back the clock’ for age-related heart conditions LOS ANGELES (EMBARGOED UNTIL AUG. 14, 2017, AT 10 A.M. EDT ) – Cardiac stem cell infusions could someday help reverse the aging process in the human heart, making older ones behave younger, according to a new study from...
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Diffusion dynamics play an essential role in regulating stem cells and tissue development
Gradients of molecular signaling factors play an essential role in numerous events in embryonic development, from patterning limb and organ formation to the intricate shaping of the brain and neuroanatomical architecture. These gradients are a consequence of diffusion dynamics in tissues, and newly published work describes two vital aspects of these diffusion processes in tissue...
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What makes stem cells into perfect allrounders
Stem cells are considered biological allrounders because they have the potential to develop into the various body cell types. For the majority of stem cells, however, this designation is too far-reaching. Adult stem cells, for example, can replace cells in their own tissue in case of injury, but a fat stem cell will never generate...